{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T19:07:29Z","timestamp":1649012849356},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>We report on a patient with genetically confirmed adrenal hypoplasia congenita (AHC) whose presentation and laboratory abnormalities were consistent with the more common condition, congenital adrenal hyperplasia (CAH). The patient presented with failure to thrive and salt wasting. General appearance showed marked hyperpigmentation and normal male genitalia. He displayed mildly elevated 17-hydroxyprogesterone and markedly elevated 11-deoxycortisol levels at baseline and with ACTH stimulation testing. Results were consistent with 11<jats:italic>\u03b2<\/jats:italic>-hydroxylase deficiency. He required glucocorticoids and high doses of mineralocorticoids. The marked elevation in 11-deoxycortisol directed our clinical reasoning away from a hypoplastic condition and towards a hyperplasic adrenal condition. Sequencing of the DAX1 gene (named for dosage-sensitive sex reversal (DSS) locus and the AHC locus on the X chromosome) revealed a missense mutation. A review of the literature revealed that elevated 11-deoxycortisol levels have been noted in kindreds with DAX1 mutations, but only when measured very early in life. A mouse model has recently been described that displays elevated 11-deoxycorticosterone levels and evidence for hyperplasia of the zona glomerulosa of the adrenal gland. We conclude that DAX1 testing may be considered in patients with laboratory evidence of 11<jats:italic>\u03b2<\/jats:italic>-hydroxylase deficiency, especially in those with severe salt wasting.<\/jats:p>","DOI":"10.1155\/2013\/393584","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T21:01:23Z","timestamp":1360702883000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Adrenal Hypoplasia Congenita Presenting as Congenital Adrenal Hyperplasia"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jennifer L.","family":"Flint","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill D.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.504"},{"issue":"6507","key":"2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/372635a0","volume":"372","year":"1994","journal-title":"Nature"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81172-1"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3109\/07435800009048628","volume":"26","year":"2000","journal-title":"Endocrine Research"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.8.2666"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.108567"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.7.3171"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1498"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/jcem-63-1-36","volume":"63","year":"1986","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"11","key":"10","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/adc.59.11.1092","volume":"59","year":"1984","journal-title":"Archives of Disease in Childhood"},{"issue":"2","key":"11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1210\/jcem-58-2-384","volume":"58","year":"1984","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0986"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0260011"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01010-08"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0133"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/stem.78"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.12.010"},{"issue":"4","key":"18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/jcem-60-4-631","volume":"60","year":"1985","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"10","key":"19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF03350043","volume":"12","year":"1989","journal-title":"Journal of Endocrinological Investigation"},{"issue":"5","key":"20","first-page":"487","volume":"21","year":"2008","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1890"},{"issue":"7","key":"22","first-page":"945","volume":"13","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/393584.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/393584.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/393584.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T07:24:15Z","timestamp":1498029855000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crie\/2013\/393584\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":22,"alternative-id":["393584","393584"],"URL":"https:\/\/doi.org\/10.1155\/2013\/393584","relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}