{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:31:28Z","timestamp":1752982288199,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Orthopedics"],"published-print":{"date-parts":[[2013,2,11]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Traditionally, osteolysis around total knee replacements (TKRs) is treated with complete revision. In certain subsets, polyethylene insert exchange and bone grafting may be applicable. This study reports the clinical outcomes for selective bone grafting in patients with osteolysis without complete revision of the TKR. <jats:italic>Methods.<\/jats:italic> This retrospective study analyzes 10 TKRs (9 patients, 66.5 \u00b1 6.1 years old) presenting with osteolysis and revised after 8.7 \u00b1 1.9 years of in vivo function. At index TKR, all patients were implanted with uncemented prosthesis and modular polyethylene insert with anteroposterior articular constraint (Ultracongruent, Natural Knee II, Sulzer Medica). The surgical technique for treating the osteolysis included removal of necrotic bone tissue using curettage, filling of the defect with bone graft materials, and polyethylene insert exchange. <jats:italic>Results.<\/jats:italic> Patients have not exhibited any further complications associated with osteolysis after 5.1 \u00b1 2.4 years of followup. Routine radiographic exams show total incorporation of the graft material into the previously lytic regions in all patients. <jats:italic>Conclusion.<\/jats:italic> In some TKRs with osteolysis and firmly fixed components, the removal of lytic tissue and subsequent defect filling with bone graft materials can be a viable solution. This case series shows complete resolution of osteolysis in all patients with no complications.<\/jats:p>","DOI":"10.1155\/2013\/398298","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T21:10:15Z","timestamp":1360617015000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Treatment for Wear and Osteolysis in Well-Fixed Uncemented TKR"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-6095","authenticated-orcid":true,"given":"Leah","family":"Nunez","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Clemson University, Clemson, SC 29634, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-2680","authenticated-orcid":true,"given":"Brandon","family":"Broome","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Clemson University, Clemson, SC 29634, USA"},{"name":"Steadman Hawkins Clinic of 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