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Historically, cell-mediated immunity and innate immunity are considered to be the most important lines of defense against candidiasis. Nevertheless recent evidence demonstrates that antibodies with defined specificities could act with different degrees showing protection against systemic and mucosal candidiasis. Mycograb is a human recombinant monoclonal antibody against heat shock protein 90 (Hsp90) that was revealed to have synergy when combined with fluconazole, caspofungin, and amphotericin B against a broad spectrum of<jats:italic>Candida<\/jats:italic>species. Furthermore, recent studies have established an important role for Hsp90 in mediating<jats:italic>Candida<\/jats:italic>resistance to echinocandins, giving to this antibody molecule even more attractive biological properties. In response to the failure of marketing authorization by the CHMP (Committee for Medicinal Products for Human Use) a new formulation of Mycograb, named Mycograb C28Y variant, with an amino acid substitution was developed in recent years. First data on Mycograb C28Y variant indicate that this monoclonal antibody lacked efficacy in a murine candidiasis model.<\/jats:p>","DOI":"10.1155\/2013\/403121","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T21:02:13Z","timestamp":1372280533000},"page":"1-9","source":"Crossref","is-referenced-by-count":64,"title":["Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9038-3233","authenticated-orcid":true,"given":"Francesca","family":"Bugli","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Cacaci","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Universit\u00e0 Cattolica del Sacro Cuore, Rome, 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