{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:49:44Z","timestamp":1791150584411,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>BACKGROUND: Almost all patients with Duchenne muscular dystrophy (DMD) eventually develop respiratory failure. Once 24 h ventilation is required, either due to incomplete effectiveness of nocturnal noninvasive ventilation (NIV) or bulbar weakness, it is common practice to recommend invasive tracheostomy ventilation; however, noninvasive daytime mouthpiece ventilation (MPV) as an addition to nocturnal mask ventilation is also an alternative.<\/jats:p>\n                  <jats:p>METHODS: The authors\u2019 experience with 12 DMD patients who used 24 h NIV with mask NIV at night and MPV during daytime hours is reported.<\/jats:p>\n                  <jats:p>\n                    RESULTS: The mean (\u00b1 SD) age and vital capacity (VC) at initiation of nocturnal (only) NIV subjects were 17.8\u00b13.5 years and 0.90\u00b10.40 L (21% predicted), respectively; and, at the time of MPV, 19.8\u00b13.4 years and 0.57 L (13.2% predicted), respectively. In clinical practice, carbon dioxide (CO\n                    <jats:sub>2<\/jats:sub>\n                    ) levels were measured using different methods: arterial blood gas analysis, transcutaneous partial pressure of CO\n                    <jats:sub>2<\/jats:sub>\n                    and, predominantly, by end-tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    . While the results suggested improved CO\n                    <jats:sub>2<\/jats:sub>\n                    levels, these were not frequently confirmed by arterial blood gas measurement. The mean survival on 24 h NIV has been 5.7 years (range 0.17 to 12 years). Of the 12 patients, two deaths occurred after 3.75 and four years, respectively, on MPV; the remaining patients continue on 24 h NIV (range two months to 12 years; mean 5.3 years; median 3.5 years).\n                  <\/jats:p>\n                  <jats:p>CONCLUSIONS: Twenty-four hour NIV should be considered a safe alternative for patients with DMD because its use may obviate the need for tracheostomy in patients with chronic respiratory failure requiring more than nocturnal ventilation alone.<\/jats:p>","DOI":"10.1155\/2013\/406163","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T03:55:57Z","timestamp":1458014157000},"page":"e5-e9","source":"Crossref","is-referenced-by-count":53,"title":["Twenty-Four Hour Noninvasive Ventilation in Duchenne Muscular Dystrophy: A Safe Alternative to Tracheostomy"],"prefix":"10.1155","volume":"20","author":[{"given":"Douglas A","family":"McKim","sequence":"first","affiliation":[{"name":"Canadian Alternatives in Non-invasive Ventilation Program, Respiratory Rehabilitation Services and The Ottawa Hospital Sleep Centre, Canada"},{"name":"Department of Medicine, University of Ottawa, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Griller","sequence":"additional","affiliation":[{"name":"University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital, Rehabilitation Centre, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Woolnough","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital, Rehabilitation Centre, Canada"},{"name":"Institute for Rehabilitation Research and Development, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"King","sequence":"additional","affiliation":[{"name":"Physiotherapy Program, School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2013\/406163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2013\/406163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T05:03:25Z","timestamp":1471928605000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crj\/2013\/406163\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"alternative-id":["406163"],"URL":"https:\/\/doi.org\/10.1155\/2013\/406163","relation":{},"ISSN":["1198-2241"],"issn-type":[{"value":"1198-2241","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}