{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T22:42:59Z","timestamp":1778366579330,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Jacaranda decurrens<\/jats:italic>subsp.<jats:italic>symmetrifoliolata<\/jats:italic>Farias &amp; Proen\u00e7a (Bignoniaceae) is a species traditionally used for the treatment of inflammatory and infectious diseases. Previous findings from our group reported scientifically that<jats:italic>J. decurrens<\/jats:italic>has anti-inflammatory efficacy. However, more toxicological studies are needed to support and ensure its safe use. The present study was carried out to evaluate the toxic effects of a prolonged treatment with hydroethanolic root extract of<jats:italic>J. decurrens<\/jats:italic>(EJD) on hematological, biochemical, and reproductive parameters in adult male rats. The animals received by oral gavage 0; 250; 500; or 1000\u2009mg\/kg body weight of EJD for 28 days. After the treatment, biochemical, hematological, histopathological, and reproductive parameters were analyzed. The EJD treatment did not cause adverse effects on body weight gain, feed and water consumption, hematological and biochemical profiles, or histopathological analysis of liver and kidney. Similarly, there were no statistically significant differences in reproductive parameters, such as sperm production, number of sperm in the epididymis, and sperm morphology. These results demonstrate the absence of subacute toxicity as a result of the oral treatment with EJD for 28 days in adult male rats. However, other studies should be performed to evaluate the total safety of this plant.<\/jats:p>","DOI":"10.1155\/2013\/414821","type":"journal-article","created":{"date-parts":[[2013,11,17]],"date-time":"2013-11-17T16:04:59Z","timestamp":1384704299000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Subacute and Reproductive Oral Toxicity Assessment of the Hydroethanolic Extract of<i>Jacaranda decurrens<\/i>Roots in Adult Male Rats"],"prefix":"10.1155","volume":"2013","author":[{"given":"Joyce Alencar","family":"Santos","sequence":"first","affiliation":[{"name":"School of Health Sciences, Federal University of Grande Dourados, Caixa Postal-322, Dourados, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Arruda","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Federal University of Grande Dourados, Caixa Postal-322, Dourados, MS, 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Dourados, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Federal University of Grande Dourados, Caixa Postal-322, Dourados, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arielle Cristina","family":"Arena","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Federal University of Grande Dourados, Caixa Postal-322, Dourados, MS, Brazil"},{"name":"Department of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University (UNESP), Distrito de Rubi\u00e3o Junior, S\/N, Caixa Postal-510, 18618970 Botucatu, SP, 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