{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:02:54Z","timestamp":1740164574421,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Case reports on the development of toxic epidermal necrolysis (TEN) associated with concurrent administration of phenytoin with cranial radiation therapy (Ahmed (2004), Criton et al. (1997), and Rzany et al. (1996)), but reports about erythema multiforme, which can develop in patients treated with levetiracetam and cranial irradiation, are very limited. This paper presents evidence that TEN may be induced by concurrent use of radiation with both phenytoin and levetiracetam. Our case is a 42-year-old male patient, a case of gliosarcoma who developed purpuric dermatitis associated with phenytoin when combined with cranial radiation therapy; although phenytoin was discontinued and switched to levetiracetam, the patient had more severe symptoms of toxic epidermal necrolysis (TEN) on levetiracetam; the patient improved with aggressive symptom management, discontinuation of antiepileptic drugs (AEDs), and holding radiotherapy. Although TEN is a rare toxicity, physicians should pay a special attention to the monitoring of brain tumor patients on antiepileptic prophylaxis during cranial irradiation; furthermore, patients should be counselled to notify their physicians if they develop any new or unusual symptoms.<\/jats:p>","DOI":"10.1155\/2013\/415031","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T17:02:08Z","timestamp":1375203728000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0017-4401","authenticated-orcid":true,"given":"Shereen","family":"Elazzazy","sequence":"first","affiliation":[{"name":"Pharmacy Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taghrid","family":"Abu Hassan","sequence":"additional","affiliation":[{"name":"Pharmacy Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"El Seid","sequence":"additional","affiliation":[{"name":"Oncology Hematology Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cicy Mary","family":"Jacob","sequence":"additional","affiliation":[{"name":"Oncology Hematology Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"12","key":"2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1046\/j.1365-4362.1997.00100.x","volume":"36","year":"1997","journal-title":"International Journal of Dermatology"},{"first-page":"2085","volume-title":"Toxic epidermal necrolysis","year":"1998","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1996.tb00032.x"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1227\/00006123-198912000-00022","volume":"25","year":"1989","journal-title":"Neurosurgery"},{"issue":"10","key":"7","first-page":"747","volume":"30","year":"1991","journal-title":"International Journal of Dermatology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199006000-00023"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01934.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-49"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1212\/WNL.49.2.542","volume":"49","year":"1997","journal-title":"Neurology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05418-X"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2013\/415031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2013\/415031.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2013\/415031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T13:06:35Z","timestamp":1498050395000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crionm\/2013\/415031\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":10,"alternative-id":["415031","415031"],"URL":"https:\/\/doi.org\/10.1155\/2013\/415031","relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"type":"print","value":"2090-6706"},{"type":"electronic","value":"2090-6714"}],"subject":[],"published":{"date-parts":[[2013]]}}}