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The acronym ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) highlights that children seeking clinical treatment are often multiply impaired, thus requiring treatment from several specialties. The aim was to map and relate, on a population level, ESSENCE to two salient predictors of health and adaptation to adversities, namely, Self\u2010Directedness and Cooperativeness and also to dysfunction and suffering. <jats:italic>Methods<\/jats:italic>. Participants were twins (<jats:italic>N<\/jats:italic> = 1892) aged 9 or 12 whose parents were interviewed with the Autism\u2010Tics, ADHD and other Comorbidities inventory (A\u2010TAC), and the Junior Temperament and Character Inventory (J\u2010TCI). The A\u2010TAC was first used to discern four ESSENCE\u2010related screening diagnoses: autism spectrum disorders, attention deficit hyperactivity disorder, learning disabilities, and developmental coordination disorder; second, to quantify dysfunction and suffering in important social areas. <jats:italic>Results<\/jats:italic>. ESSENCE symptoms were continuously and categorically associated with deficiency in Self\u2010Directedness and Cooperativeness and higher ratings of dysfunction and suffering. The impact of ESSENCE symptoms on these measures of mental health was found in a milder form in about 16% of all children and in a severe form in about 2%. <jats:italic>Conclusion<\/jats:italic>. Therapeutic interventions focusing on Self\u2010Directedness and Cooperativeness might provide a novel method for child psychiatry in its approach to ESSENCE.<\/jats:p>","DOI":"10.1155\/2013\/416981","type":"journal-article","created":{"date-parts":[[2013,4,28]],"date-time":"2013-04-28T21:01:15Z","timestamp":1367182875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Self\u2010Directedness and Cooperativeness, Psychosocial Dysfunction and Suffering in ESSENCE"],"prefix":"10.1155","volume":"2013","author":[{"given":"Danilo","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Anckars\u00e4ter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Lundstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,28]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511570094"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10020223"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.059907"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.078"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijlp.2009.12.001"},{"key":"e_1_2_7_6_2","volume-title":"The Autisms","author":"Coleman M.","year":"2012"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2010.06.002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2009.02101.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000788"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.144"},{"key":"e_1_2_7_11_2","unstructured":"LarsonT. 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