{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:47:22Z","timestamp":1791074842579,"version":"4.1.0"},"reference-count":35,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis or chronic autoimmune thyroiditis, is the most common form of thyroiditis affecting more than 10% of females and 2% of males. The present study aims to evaluate the beneficial effect of a combined treatment, Myo-Inositol plus selenomethionine, on subclinical hypothyroidism.<jats:italic>Methods<\/jats:italic>. The study was designed as a double-blind randomized controlled trial. Eligible patients were women diagnosed with subclinical hypothyroidism having Tg antibodies (TgAb) titer higher than 350\u2009IU\/mL. Outcome measures were Thyroid Stimulating Hormone (TSH) levels, thyroid peroxidase antibodies (TPOAb) and TgAb titer, selenium, and Myo-Inositol plasma concentration.<jats:italic>Results<\/jats:italic>. In the present paper, we demonstrated that the beneficial effects obtained by selenomethionine treatment on patients affected by subclinical hypothyroidism, likely due to the presence of autoantibody (TPOAb and TgAb), are further improved by cotreatment with Myo-Inositol.<jats:italic>Conclusions<\/jats:italic>. Indeed, due to its action as TSH second messenger, Myo-Inositol treatment reduces TSH levels closer to physiological concentrations.<\/jats:p>","DOI":"10.1155\/2013\/424163","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T21:07:39Z","timestamp":1380748059000},"page":"1-5","source":"Crossref","is-referenced-by-count":52,"title":["Combined Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Subclinical Hypothyroidism Patients with Autoimmune Thyroiditis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Maurizio","family":"Nordio","sequence":"first","affiliation":[{"name":"University of Rome \u201cSapienza\u201d, Institute of Gynecology and Obstetrics, Viale del Policlinico, 00155 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Pajalich","sequence":"additional","affiliation":[{"name":"Ars Medica spa, Via Ferrero di Cambiano Cesare 29, 00191 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"5","key":"1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1007\/s00246-013-0638-z","volume":"34","year":"2013","journal-title":"Pediatric Cardiology"},{"issue":"6239","key":"2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/341197a0","volume":"341","year":"1989","journal-title":"Nature"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.390"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2009.009241"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0366"},{"issue":"6","key":"6","first-page":"725","volume":"9","year":"1995","journal-title":"Molecular Endocrinology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.X109.004747"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06595"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02387"},{"issue":"10","key":"10","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1242\/jcs.115.10.2139","volume":"115","year":"2002","journal-title":"Journal of Cell Science"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.008"},{"key":"12","doi-asserted-by":"crossref","first-page":"310S","DOI":"10.1093\/ajcn\/57.2.310S","volume":"57","year":"1993","journal-title":"American Journal of Clinical Nutrition"},{"key":"13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.nu.15.070195.001543","volume":"15","year":"1995","journal-title":"Annual Review of Nutrition"},{"issue":"9-10","key":"14","first-page":"849","volume":"381","year":"2000","journal-title":"Biological Chemistry"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/026010609601000401","volume":"10","year":"1996","journal-title":"Nutrition and Health"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01294-8"},{"issue":"9","key":"17","first-page":"1654","volume":"10","year":"1995","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1530\/eje.0.1330099","volume":"133","year":"1995","journal-title":"European Journal of Endocrinology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(96)03921-4"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050619"},{"issue":"8","key":"21","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1096\/fj.00-0721fje","volume":"15","year":"2001","journal-title":"The FASEB Journal"},{"issue":"5","key":"22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/152165400410263","volume":"49","year":"2000","journal-title":"IUBMB Life"},{"issue":"9225","key":"23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","volume":"356","year":"2000","journal-title":"The Lancet"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801223380401"},{"issue":"4","key":"25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/rheumatology\/31.4.281","volume":"31","year":"1992","journal-title":"British Journal of Rheumatology"},{"issue":"1","key":"26","first-page":"30","volume":"48","year":"1993","journal-title":"Allergy"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.1999.0073"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1148"},{"issue":"2","key":"29","first-page":"147","volume":"24","year":"1990","journal-title":"Biological Trace Element Research"},{"issue":"1","key":"30","first-page":"21","volume":"5","year":"1993","journal-title":"Thyroidology"},{"issue":"5","key":"31","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ajcn\/70.5.896","volume":"70","year":"1999","journal-title":"American Journal of Clinical Nutrition"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00085-2"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(93)90198-Y"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(96)00123-4"},{"issue":"10","key":"35","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1532-5415.2000.tb02603.x","volume":"48","year":"2000","journal-title":"Journal of the American Geriatrics Society"}],"container-title":["Journal of Thyroid Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2013\/424163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2013\/424163.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2013\/424163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T19:07:49Z","timestamp":1646680069000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jtr\/2013\/424163\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":35,"alternative-id":["424163","424163"],"URL":"https:\/\/doi.org\/10.1155\/2013\/424163","relation":{},"ISSN":["2090-8067","2042-0072"],"issn-type":[{"value":"2090-8067","type":"print"},{"value":"2042-0072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}