{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:57:07Z","timestamp":1781341027290,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100009843","name":"South Australian Health and Medical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009843","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Nonsteroidal-anti-inflammatory-drug (NSAID) enteropathy is characterized by small intestinal damage and ulceration. Emu Oil (EO) has previously been reported to reduce intestinal inflammation.<jats:italic>Aim<\/jats:italic>. We investigated EO for its potential to attenuate NSAID-enteropathy in rats.<jats:italic>Methods<\/jats:italic>. Male Sprague Dawley rats (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:mrow><\/mml:math>\/group) were gavaged with Water, Olive Oil (OO), or EO (0.5\u2009mL; days 0\u201312) and with 0.5\u2009mL Water or the NSAID, Indomethacin (8\u2009mg\/kg; days 5\u201312) daily. Disease activity index (DAI), 13C-sucrose breath test (SBT), organ weights, intestinal damage severity (IDS), and myeloperoxidase (MPO) activity were assessed.<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>was considered significant.<jats:italic>Results<\/jats:italic>. In Indomethacin-treated rats, DAI was elevated (days 10\u201312) and SBT values (56%) and thymus weight (55%) were decreased, relative to normal controls. Indomethacin increased duodenum (68%), colon (24%), SI (48%), caecum (48%), liver (51%) and spleen (88%) weights, IDS scores, and MPO levels (jejunum: 195%, ileum: 104%) compared to normal controls. Jejunal MPO levels were decreased (64%) by both EO and OO, although only EO decreased ileal MPO (50%), compared to Indomethacin controls.<jats:italic>Conclusions<\/jats:italic>. EO reduced acute intestinal inflammation, whereas other parameters of Indomethacin-induced intestinal injury were not affected significantly. Increased EO dose and\/or frequency of administration could potentially improve clinical efficacy.<\/jats:p>","DOI":"10.1155\/2013\/429706","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T20:03:15Z","timestamp":1363291395000},"page":"1-10","source":"Crossref","is-referenced-by-count":28,"title":["Emu Oil Reduces Small Intestinal Inflammation in the Absence of Clinical Improvement in a Rat Model of Indomethacin-Induced Enteropathy"],"prefix":"10.1155","volume":"2013","author":[{"given":"Suzanne M.","family":"Abimosleh","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Women's and Children's Hospital, North Adelaide, SA 5006, Australia"},{"name":"Discipline of Physiology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong 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