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The anti\u2010inflammatory effect was evaluated using four animal models including xylene\u2010induced mouse ear edema, acetic acid\u2010induced mouse vascular permeability, carrageenan\u2010induced mouse pleurisy, and carrageenan\u2010induced mouse hind paw edema. Results indicated that oral administration of ERP (120, 240, and 480\u2009mg\/kg) significantly attenuated xylene\u2010induced ear edema, decreased acetic acid\u2010induced capillary permeability, inhibited carrageenan\u2010induced neutrophils recruitment, and reduced carrageenan\u2010induced paw edema, in a dose\u2010dependent manner. Histopathologically, ERP (480\u2009mg\/kg) abated inflammatory response of the edema paw. Preliminary mechanism studies demonstrated that ERP decreased the level of MPO and MDA, increased the activities of anti\u2010oxidant enzymes (SOD, GPx, and GRd), attenuated the productions of TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, PGE<jats:sub>2<\/jats:sub> and NO, and suppressed the activities of COX\u20102 and iNOS. This work demonstrates that ERP has considerable anti\u2010inflammatory potential, which provided experimental evidences for the traditional application of the root and rhizome of <jats:italic>Pogostemon cablin<\/jats:italic> in inflammatory diseases.<\/jats:p>","DOI":"10.1155\/2013\/434151","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T21:01:40Z","timestamp":1386622900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Anti\u2010Inflammatory Property of the Ethanol Extract of the Root and Rhizome of <i>Pogostemon cablin<\/i> (Blanco) Benth"],"prefix":"10.1155","volume":"2013","author":[{"given":"Chu-Wen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-731X","authenticated-orcid":false,"given":"Xiao-Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ning","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu-Qing","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1124-0312","authenticated-orcid":false,"given":"Hai-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Fang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-8744","authenticated-orcid":false,"given":"Jian-Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-3207","authenticated-orcid":false,"given":"Zi-Ren","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70215-0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-5688-5_1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2011-130291"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2013.739602"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2009.12.006"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem176"},{"key":"e_1_2_7_8_2","first-page":"42","volume-title":"Pharmacopoeia of the People\u2032s Republic of China","author":"China Pharmacopoeia Commission","year":"2010"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.09.003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep183"},{"key":"e_1_2_7_11_2","volume-title":"Pharmacognosy","author":"Luo J. 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