{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:05:44Z","timestamp":1791198344096,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Drug Delivery"],"published-print":{"date-parts":[[2013,3,25]]},"abstract":"<jats:p>Drug delivery systems can provide enhanced efficacy and\/or reduced toxicity for anticancer agents. Liposome drug delivery systems are able to modify the pharmacokinetics \nand biodistribution of cytostatic agents, increasing the concentration of the drug released to neoplastic tissue and reducing the exposure of normal tissue. Anthracyclines are a key drug in the treatment of both metastatic and early breast cancer, but one of their major limitations is cardiotoxicity. One of the strategies designed to minimize this side effect is liposome encapsulation. Liposomal anthracyclines have achieved highly efficient drug encapsulation and they have proven to be effective and with reduced cardiotoxicity, as a single agent or in combination with other drugs for the treatment of either anthracyclines-treated or na\u00efve metastatic breast cancer patients. Of particular interest is the use of the combination of liposomal anthracyclines and trastuzumab in patients with HER2-overexpressing breast cancer. In this paper, we discuss the different studies on liposomal doxorubicin in metastatic and early breast cancer therapy.<\/jats:p>","DOI":"10.1155\/2013\/456409","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T17:04:19Z","timestamp":1364231059000},"page":"1-12","source":"Crossref","is-referenced-by-count":145,"title":["Liposomal Doxorubicin in the Treatment of Breast Cancer Patients: A Review"],"prefix":"10.1155","volume":"2013","author":[{"given":"Juan","family":"Lao","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Miguel Servet University Hospital, Paseo Isabel la Cat\u00f3lica, 1-3, 50009 Zaragoza, Spain"},{"name":"Arag\u00f3n Institute of Health Sciences, Avda. 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