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The present studies determined how high-fat feeding and body weight gain alter the sensitivity to the feeding suppression and neural activation to a selective norepinephrine reuptake inhibitor, nisoxetine. Acute administration of nisoxetine (saline: 0, 3, 10, and 30\u2009mg\/kg; IP) resulted in a dose-dependent reduction in the 24\u2009h refeeding response in male Sprague Dawley rats maintained on standard chow. In a similar fashion, nisoxetine resulted in reductions in blood pressure and a compensatory increase in heart rate. From these studies, the 3\u2009mg\/kg dose was subthreshold. In a separate experiment, however, 10 wk exposure to a high-fat diet (60% fat) resulted in weight gain and significant feeding suppression following administration of nisoxetine (3\u2009mg\/kg) compared with animals fed a control diet (10% fat). Nisoxetine (3\u2009mg\/kg) also resulted in greater neural activation, as measured by c-Fos immunohistochemistry, in the arcuate nucleus of the hypothalamus in animals exposed to the high-fat diet. Such data indicate acute nisoxetine doses that suppress food intake can impact cardiovascular measures. It also suggests that the feeding suppression to a low-dose nisoxetine is enhanced as a result of high-fat diet and weight gain.<\/jats:p>","DOI":"10.1155\/2013\/457047","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T16:02:41Z","timestamp":1359561761000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["High-Fat Diet-Induced Alterations in the Feeding Suppression of Low-Dose Nisoxetine, a Selective Norepinephrine Reuptake Inhibitor"],"prefix":"10.1155","volume":"2013","author":[{"given":"Nicholas T.","family":"Bello","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA"},{"name":"Graduate Program in Endocrinology and Animal Biosciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, 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