{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:43:55Z","timestamp":1753886635766,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>When a <jats:italic>Staphylococcus<\/jats:italic>\u2010like organism (SLO) is microscopically found in Gram staining of blood culture (BC) specimen, it seems reasonable to administrate a glycopeptide (GP) for empirical therapy. The paper investigates the risk factors for 14\u2010day mortality in patients with methicillin\u2010resistance <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia (MRSAB) and clarifies the impact of the timing for initiating GP therapy. A retrospective study identifies patients with MRSAB (endocarditis was excluded) between 2006 and 2009. Patients were categorized as receiving GP at the interval before a preliminary BC report indicating the growth of SLO and the onward 24 hours or receiving GP 24\u2009h after a preliminary BC report indicating the growth of SLO. Total 339 patients were enrolled. There was no difference on the 14\u2010day overall or infection\u2010related mortality rates at the time to administer GP. Multivariate analysis disclosed pneumonia (OR = 4.47; of 95% CI; of 2.09\u20139.58; <jats:italic>P<\/jats:italic> &lt; 0.01) and high APACHE II score (OR, 2.81, with 95% CI, 1.19\u20136.65; <jats:italic>P<\/jats:italic> = 0.02) were independent risk factors for infection\u2010related mortality. The mortality rate did not decrease following administrating GP immediately after a preliminary BC indicating SLO growth. An additional research for the optimal timing for initiating GP treatment is warranted.<\/jats:p>","DOI":"10.1155\/2013\/457435","type":"journal-article","created":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T21:00:31Z","timestamp":1358715631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Timing of Initiating Glycopeptide Therapy for Methicillin\u2010Resistant <i>Staphylococcus aureus<\/i> Bacteremia: The Impact on Clinical Outcome"],"prefix":"10.1155","volume":"2013","author":[{"given":"Chen-Hsiang","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chih","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jien-Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,20]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.05.013"},{"key":"e_1_2_7_2_2","first-page":"438","article-title":"Clinical significance of potential contaminants in blood cultures among patients in a medical center","volume":"40","author":"Lee C. 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