{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T21:53:24Z","timestamp":1763070804412,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Leprosy is a debilitating infectious disease of human skin and nerves. Genetics factors of the host play an important role in the disease susceptibility. Toll-interacting protein (TOLLIP) is an inhibitory adaptor protein within the toll-like receptor (TLR) pathway, which recognizes structurally conserved molecular patterns of microbial pathogens, initiating immune responses. The objective of this study was to investigate the association of variants in the<jats:italic>TOLLIP<\/jats:italic>gene with susceptibility to leprosy in Mexican patients.<jats:italic>Methods<\/jats:italic>.<jats:italic>TOLLIP<\/jats:italic>polymorphisms were studied using a case-control design of Mexican patients with lepromatous leprosy (LL). The polymorphisms of<jats:italic>TOLLIP<\/jats:italic>at loci \u2212526 C&gt;G (rs5743854), 1309956C&gt;T (rs3750920), 1298430C&gt;A (rs5744015), and 1292831 G&gt;A (rs3750919) were analyzed by PCR, with sequence-specific primers in LL patients and healthy subjects (HS) as controls.<jats:italic>Results<\/jats:italic>. Genotype distributions were in Hardy Weinberg equilibrium for all sites except for rs3750920. Neither genotype nor allele frequencies were statistically different between LL patients and controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The maximum pairwise D\u2019 coefficient reached was 0.44 of linkage (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) for all the polymorphisms except for rs5743854. The three loci haplotype comparison yielded no significant differences between groups.<jats:italic>Conclusions<\/jats:italic>. Just the individuals with genotype C\/C of rs3750920 have a trend of protective effect to developing LL.<\/jats:p>","DOI":"10.1155\/2013\/459169","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T21:02:02Z","timestamp":1383598922000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Role of Toll-Interacting Protein Gene Polymorphisms in Leprosy Mexican Patients"],"prefix":"10.1155","volume":"2013","author":[{"given":"Margarita","family":"Montoya-Buelna","sequence":"first","affiliation":[{"name":"Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1, Jal., Mexico"},{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-1175","authenticated-orcid":true,"given":"Mary","family":"Fafutis-Morris","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., Mexico"},{"name":"CIINDE Universidad de Guadalajara\/Instituto Dermatol\u00f3gico de Jalisco \u201cDr. Jose Barba Rubio\u201d, Sierra Mojada 950, Edificio P. Primer Nivel, Colonia Independencia, 44340 Guadalajara, Jal., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro J.","family":"Tovar-Cuevas","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anabell","family":"Alvarado-Navarro","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., Mexico"},{"name":"CIINDE Universidad de Guadalajara\/Instituto Dermatol\u00f3gico de Jalisco \u201cDr. Jose Barba Rubio\u201d, Sierra Mojada 950, Edificio P. Primer Nivel, Colonia Independencia, 44340 Guadalajara, Jal., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeminia","family":"Valle","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge R.","family":"Padilla-Gutierrez","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose F.","family":"Mu\u00f1oz-Valle","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Figuera-Villanueva","sequence":"additional","affiliation":[{"name":"Genetic Division Department, 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