{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:42:57Z","timestamp":1791891777577,"version":"4.3.4"},"reference-count":35,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Karadeniz Technical University","award":["2009.111.002.5"],"award-info":[{"award-number":["2009.111.002.5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Bee pollen has been used as an apitherapy agent for several centuries to treat burns, wounds, gastrointestinal disorders, and various other diseases. The aim of our study was to investigate the hepatoprotective effects of chestnut bee pollen against carbon tetrachloride (CCI<jats:sub>4<\/jats:sub>)-induced liver damage. Total phenolic content, flavonoid, ferric reducing\/antioxidant power, and DPPH radical activity measurements were used as antioxidant capacity determinants of the pollen. The study was conducted in rats as seven groups. Two different concentrations of chestnut bee pollens (200 and 400\u2009mg\/kg\/day) were given orally and one group was administered with silibinin (50\u2009mg\/kg\/day, i.p.) for seven days to the rats following the CCI<jats:sub>4<\/jats:sub>treatment. The protective effect of the bee pollen was monitored by aspartate transaminase (AST) and alanine transaminase (AST) activities, histopathological imaging, and antioxidant parameters from the blood and liver samples of the rats. The results were compared with the silibinin-treated and untreated groups. We detected that CCI<jats:sub>4<\/jats:sub>treatment induced liver damage and both the bee pollen and silibinin-treated groups reversed the damage; however, silibinin caused significant weight loss and mortality due, severe diarrhea in the rats. The chestnut pollen had showed 28.87\u2009mg GAE\/g DW of total phenolic substance, 8.07\u2009mg QUE\/g DW of total flavonoid, 92.71\u2009mg Cyn-3-glu\/kg DW of total anthocyanins, and 9\u2009mg<jats:italic>\u03b2<\/jats:italic>-carotene\/100\u2009g DW of total carotenoid and substantial amount of antioxidant power according to FRAP and DPPH activity. The results demonstrated that the chestnut bee pollen protects the hepatocytes from the oxidative stress and promotes the healing of the liver damage induced by CCI<jats:sub>4<\/jats:sub>toxicity. Our findings suggest that chestnut bee pollen can be used as a safe alternative to the silibinin in the treatment of liver injuries.<\/jats:p>","DOI":"10.1155\/2013\/461478","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T21:40:54Z","timestamp":1382478054000},"page":"1-9","source":"Crossref","is-referenced-by-count":62,"title":["Hepatoprotective Potential of Chestnut Bee Pollen on Carbon Tetrachloride-Induced Hepatic Damages in Rats"],"prefix":"10.1155","volume":"2013","author":[{"given":"Oktay","family":"Y\u0131ld\u0131z","sequence":"first","affiliation":[{"name":"Ma\u00e7ka Vocational School, Karadeniz Technical University, 61750 Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, Karadeniz Technical University, 61080 Trabzon, 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