{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T01:27:34Z","timestamp":1745198854995,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Ehlers-Danlos syndrome type VIII (EDS-VIII) is a very rare autosomal dominant disease characterized by early-onset periodontitis associated with features of Ehlers-Danlos syndrome. We report a 32-year-old man whose chronic leg ulcer led to the diagnosis of EDS-VIII. He had severe periodontitis with complete loss of permanent teeth and skin fragility with thin skin, atrophic scars, and brownish atrophic pretibial plaques. Leg ulcer is not a prominent feature of EDS-VIII. We suggest adding EDS-VIII to the list of rare diseases accounting for chronic leg ulcers, if this case report prompts others to report leg ulcers associated with EDS-VIII.<\/jats:p>","DOI":"10.1155\/2013\/469505","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T17:02:56Z","timestamp":1380819776000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["Ehlers-Danlos Syndrome Type VIII: A Rare Cause of Leg Ulcers in Young Patients"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-0079","authenticated-orcid":true,"given":"Sophie","family":"Ronceray","sequence":"first","affiliation":[{"name":"Department of Dermatology, Pontchaillou University Hospital, 2 Rue Henri Le Guilloux, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-8322","authenticated-orcid":true,"given":"Juliette","family":"Miquel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pontchaillou University Hospital, 2 Rue Henri Le Guilloux, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Pontchaillou University Hospital, 2 Rue Henri Le Guilloux, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rald E.","family":"Pi\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, Sart-Tilman University Hospital, B-4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trinh","family":"Hermanns-L\u00ea","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, Sart-Tilman University Hospital, B-4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"De Paepe","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Ghent University Hospital, B-9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pontchaillou University Hospital, 2 Rue Henri Le Guilloux, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"1972","key":"1"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1016\/j.jaad.2006.02.024"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1086\/376416"},{"issue":"2","key":"4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ejhg.2012.132","volume":"21","year":"2013","journal-title":"European Journal of Human Genetics"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2133.1993.tb00211.x","volume":"128","year":"1993","journal-title":"British Journal of Dermatology"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1111\/j.1365-2133.2008.08434.x"},{"volume":"76, article 422","year":"1981","journal-title":"Journal of Investigative Dermatology","key":"7"},{"issue":"4","key":"8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/ajmg.1320370408","volume":"37","year":"1990","journal-title":"American Journal of Medical Genetics"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1002\/ajmg.a.33914"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1016\/j.annder.2009.11.009"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1056\/NEJM200003093421001"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1111\/j.1399-0004.2012.01858.x"},{"volume-title":"Manifestations cutan\u00e9es des alt\u00e9rations vasculaires et neurologiques des membres inf\u00e9rieurs","year":"2009","first-page":"747","key":"13"},{"year":"2008","key":"14"},{"volume-title":"Cutaneous changes in venous and lymphatic insufficiency","year":"2008","first-page":"1679","key":"15"},{"key":"16","first-page":"1","volume-title":"Diseases of the veins and arteries: leg ulcers","volume":"3","year":"2010"},{"key":"17","first-page":"405","volume-title":"Skin manifestations of internal disease","volume":"1","year":"2012"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2013\/469505.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2013\/469505.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2013\/469505.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T19:05:24Z","timestamp":1498071924000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cridm\/2013\/469505\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":17,"alternative-id":["469505","469505"],"URL":"https:\/\/doi.org\/10.1155\/2013\/469505","relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"type":"print","value":"2090-6463"},{"type":"electronic","value":"2090-6471"}],"subject":[],"published":{"date-parts":[[2013]]}}}