{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:26:17Z","timestamp":1760984777363},"reference-count":20,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Otolaryngology"],"published-print":{"date-parts":[[2013,6,20]]},"abstract":"<jats:p>Genetic predisposition of otosclerosis has long been suspected, but unclarified. Unique coexpression pattern of measles virus receptor (CD46) splicing isoforms in the human otic capsule is assumed, since otosclerosis is a measles virus-associated organ-specific disease. In order to identify CD46 involved in the pathogenesis of otosclerosis, we used representative groups of histologically diagnosed otosclerotic, nonotosclerotic, and normal stapes footplates<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>109<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>. Consecutive histopathological examinations and CD46-specific Western blot analysis were performed. Normal and nonotosclerotic stapes footplates showed consistent expression of the conventional<jats:italic>c, d, e, f<\/jats:italic>, and<jats:italic>l<\/jats:italic>CD46 isoforms. In contrast, four novel isoforms<jats:italic>(os1\u20134)<\/jats:italic>translated as intact proteins were additionally detected in each otosclerotic specimen. The study herein presented provides evidence for the otosclerosis-associated expression pattern of CD46. This finding might explain the organ-specific, virus-associated and autoimmune-inflammatory pathogenesis of otosclerosis. Regarding our current knowledge, this is the first report that confirms the presence of four new disease-specific protein variants of CD46.<\/jats:p>","DOI":"10.1155\/2013\/479482","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T21:20:17Z","timestamp":1371763217000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Detection of Otosclerosis-Specific Measles Virus Receptor (Cd46) Protein Isoforms"],"prefix":"10.1155","volume":"2013","author":[{"given":"Bal\u00e1zs","family":"Liktor","sequence":"first","affiliation":[{"name":"Bajcsy-Zsilinszky Hospital, Department of Otolaryngology, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Csomor","sequence":"additional","affiliation":[{"name":"University of Debrecen, Medical and Health Science Center, Department of Rheumatology, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Karosi","sequence":"additional","affiliation":[{"name":"University of Debrecen, Medical and Health Science Center, Department of Otolaryngology and Head and Neck Surgery, Nagyerdei Krt. 98, Debrecen 4032, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"11","key":"1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1288\/00005537-198511000-00003","volume":"95","year":"1985","journal-title":"Laryngoscope"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/00129492-200109000-00006","volume":"22","year":"2001","journal-title":"Otology and Neurotology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.03.009"},{"issue":"2","key":"4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00129492-200103000-00023","volume":"22","year":"2001","journal-title":"Otology and Neurotology"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0030-6665(20)30813-6","volume":"26","year":"1993","journal-title":"Otolaryngologic Clinics of North America"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817c133d"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000204142.80263.2b"},{"issue":"1","key":"8","first-page":"25","volume":"7","year":"1986","journal-title":"American Journal of Otology"},{"issue":"10","key":"9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1017\/S0022215100106693","volume":"102","year":"1988","journal-title":"Journal of Laryngology and Otology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00679-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.430"},{"issue":"5272","key":"12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.273.5272.228","volume":"273","year":"1996","journal-title":"Science"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00917.x"},{"issue":"6","key":"14","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/00007890-200003270-00018","volume":"69","year":"2000","journal-title":"Transplantation"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0470-3"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00794.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071112"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm150"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.01.023"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181be6af4"}],"container-title":["ISRN Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/479482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/479482.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/479482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:31:16Z","timestamp":1715538676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2013\/479482\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":20,"alternative-id":["479482","479482"],"URL":"https:\/\/doi.org\/10.1155\/2013\/479482","relation":{},"ISSN":["2090-5750"],"issn-type":[{"value":"2090-5750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]}}}