{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:47:09Z","timestamp":1791121629753,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerio de Educaci\u00f3n y Ciencia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland<jats:italic>in vivo<\/jats:italic>(rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and<jats:italic>in vitro<\/jats:italic>(adenopituitary cell cultures treated with the adipokine). Here, by a combination of<jats:italic>in vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.<\/jats:p>","DOI":"10.1155\/2013\/479739","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T17:05:52Z","timestamp":1366304752000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Resistin Regulates Pituitary Lipid Metabolism and Inflammation<i>In Vivo<\/i>and<i>In Vitro<\/i>"],"prefix":"10.1155","volume":"2013","author":[{"given":"F.","family":"Rodriguez-Pacheco","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Spain"},{"name":"Endocrinology and Nutrition Service, Carlos Hay\u00e0 Hospital, Fundaci\u00f3n IMABIS, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Novelle","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Garcia-Escobar","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Carlos Hay\u00e0 Hospital, Fundaci\u00f3n IMABIS, 29009 M\u00e1laga, Spain"},{"name":"CIBER Diabetes and Metabolic Illness (CIBER-DEM), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Soriguer","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Carlos Hay\u00e0 Hospital, Fundaci\u00f3n IMABIS, 29009 M\u00e1laga, Spain"},{"name":"CIBER Diabetes and Metabolic Illness (CIBER-DEM), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rojo-Martinez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Carlos Hay\u00e0 Hospital, Fundaci\u00f3n IMABIS, 29009 M\u00e1laga, Spain"},{"name":"CIBER Diabetes and Metabolic Illness (CIBER-DEM), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Garc\u00eda-Fuentes","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Carlos Hay\u00e0 Hospital, Fundaci\u00f3n IMABIS, 29009 M\u00e1laga, Spain"},{"name":"CIBER Diabetes and Metabolic Illness (CIBER-DEM), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Malagon","sequence":"additional","affiliation":[{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Spain"},{"name":"Department of Cellular Biology, Physiology and Inmunology, School of Siences, University of C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dieguez","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0263"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4536"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1677"},{"issue":"8","key":"4","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/oby.2005.173","volume":"13","year":"2005","journal-title":"Obesity"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05866"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4382"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1172\/JCI112855","volume":"79","year":"1987","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1172\/JCI116186","volume":"91","year":"1993","journal-title":"Journal of Clinical Investigation"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2011.002"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.4.912"},{"issue":"10","key":"12","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1073\/pnas.84.10.3434","volume":"84","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.380"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1332"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.01.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1705-7"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.8.3717"},{"key":"18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1210\/endo-69-2-225","volume":"69","year":"1961","journal-title":"Endocrinology"},{"issue":"4572","key":"19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1126\/science.6812220","volume":"218","year":"1982","journal-title":"Science"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611008104"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.1.281"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222657499"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222657499"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1500"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.6.2785"},{"issue":"9","key":"26","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1210\/endo.136.9.7649123","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.12.8.1385"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.3.1097"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1677\/JME-09-0063"},{"issue":"2","key":"30","first-page":"E299","volume":"270","year":"1996","journal-title":"The American Journal of Physiology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000256090.42690.05"},{"issue":"5","key":"32","first-page":"519","volume":"7","year":"2007","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1336"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108324"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2013\/479739.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2013\/479739.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2013\/479739.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T07:39:23Z","timestamp":1498030763000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/mi\/2013\/479739\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":33,"alternative-id":["479739","479739"],"URL":"https:\/\/doi.org\/10.1155\/2013\/479739","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}