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Nevertheless, gender-related differences have not been thoroughly explored in psoriatic arthritis (PsA). In PsA, males accumulate more peripheral and axial joint damage compared to women. However, it is not clear whether these findings are secondary to differences in occupational physical activity, hormonal changes, or other factors. The present study analyzed the differences in clinical expression of PsA between men and women. We have also evaluated the possible existence of gender-linked differences in the distribution of genes and polymorphisms within the major histocompatibility complex and whether patients\u2019 age at the onset of psoriasis established any differences in these aspects. Women suffered more polyarthritis, greater functional impairment, and a larger number of swollen joints during followup. We appreciated a differential expression of certain MHC genes according to gender and age at onset of psoriasis. Our results point to the need to include patient\u2019s age at the onset of psoriasis and gender as key stratification elements in future studies of genetic associations in PsA.<\/jats:p>","DOI":"10.1155\/2013\/482691","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T21:06:35Z","timestamp":1366146395000},"page":"1-7","source":"Crossref","is-referenced-by-count":49,"title":["Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Rub\u00e9n","family":"Queiro","sequence":"first","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C\/Celestino Villamil s\/n, Oviedo, 33006 Asturias, Spain"},{"name":"Psoriasis Unit, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, 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