{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:20:00Z","timestamp":1760646000670},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sarcoma"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background and Objectives<\/jats:italic>. Atypical lipomas are uncommon, slow-growing benign tumors. While surgery has been the primary treatment modality, we have managed some patients with radiation (RT) as a component of the treatment and have reported their outcomes in this study.<jats:italic>Methods<\/jats:italic>. A retrospective review of all cases of extremity and trunk atypical lipomas in The Sarcoma Database at the study institution was conducted.<jats:italic>Results<\/jats:italic>. Thirteen patients were identified. All patients underwent surgical resection at initial presentation and received pre- or postoperative radiation for subtotal resection (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:math>), local recurrence (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>8<\/mml:mn><\/mml:mrow><\/mml:math>), or progressive disease (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:math>). The median total radiation dose was 50\u2009Gy. Median followup was 65.1 months. All patients treated with RT remained free of disease at the last followup. No grade 3 or higher late toxicity from radiation was observed. No cases of tumor dedifferentiation occurred.<jats:italic>Conclusion<\/jats:italic>. For recurrent or residual atypical lipomas, a combination of reexcision and RT can provide long-term local control with acceptable morbidity. For recurrent tumors, pre-op RT of 50\u2009Gy appears to be an effective and well-tolerated management approach.<\/jats:p>","DOI":"10.1155\/2013\/485483","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T16:08:14Z","timestamp":1358266094000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["The Use of Radiation Therapy in the Management of Selected Patients with Atypical Lipomas"],"prefix":"10.1155","volume":"2013","author":[{"given":"Josephine","family":"Kang","sequence":"first","affiliation":[{"name":"Harvard Radiation Oncology Program, Boston, MA 02215, USA"},{"name":"Flushing Radiation Oncology Services, Queens, NY 11354, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maikel","family":"Botros","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saveli","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Giraud","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Petur","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Raskin","sequence":"additional","affiliation":[{"name":"Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Orthopaedic Oncology, Massachusetts General Hospital, Boston, MA 02114, 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