{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:53:51Z","timestamp":1774367631738,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Traditional Chinese Medicine Program of Zhejiang Province China","award":["2010ZA053"],"award-info":[{"award-number":["2010ZA053"]}]},{"name":"Traditional Chinese Medicine Program of Zhejiang Province China","award":["2011RCB019"],"award-info":[{"award-number":["2011RCB019"]}]},{"name":"Medicine & Health Program of Zhejiang Province China","award":["2010ZA053"],"award-info":[{"award-number":["2010ZA053"]}]},{"name":"Medicine & Health Program of Zhejiang Province China","award":["2011RCB019"],"award-info":[{"award-number":["2011RCB019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however,<jats:italic>H. pylori<\/jats:italic>positivity and inflammatory activity decreased significantly with increased age.<jats:italic>H. pylori<\/jats:italic>infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with<jats:italic>H. pylori<\/jats:italic>infection were found to have simultaneous inflammatory activity. The intestinal metaplasia and dysplasia positivity markedly increased as the degree of gastric atrophy increased. In conclusion, the incidence of<jats:italic>H. pylori<\/jats:italic>infection decreased with age and correlated significantly with inflammatory activity in atrophic gastritis patients. The intestinal metaplasia and dysplasia positivity notably increased as the degree of gastric atrophy increased. Large population-based prospective studies are needed to better understand the progression of CAG.<\/jats:p>","DOI":"10.1155\/2013\/494783","type":"journal-article","created":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T21:18:14Z","timestamp":1379971094000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["The Prevalence of<i>Helicobacter pylori<\/i>Infection Decreases with Older Age in Atrophic Gastritis"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-1233","authenticated-orcid":true,"given":"Shaohua","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixiong","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Zhejiang Hospital, Hangzhou 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2857"},{"issue":"4","key":"3","first-page":"248","volume":"64","year":"2010","journal-title":"Medicinski Arhiv"},{"issue":"10","key":"4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","volume":"20","year":"1996","journal-title":"The American Journal of Surgical Pathology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.02.026"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03031.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i41.5181"},{"issue":"7318","key":"8","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1136\/bmj.323.7318.920","volume":"323","year":"2001","journal-title":"British Medical Journal"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/infdis\/169.2.434","volume":"169","year":"1994","journal-title":"Journal of Infectious Diseases"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i42.4682"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/gut.37.3.319","volume":"37","year":"1995","journal-title":"Gut"},{"issue":"3","key":"12","first-page":"270","volume":"11","year":"2008","journal-title":"Nigerian Journal of Clinical Practice"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00550.x"},{"issue":"8964","key":"14","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(95)91084-0","volume":"345","year":"1995","journal-title":"The Lancet"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a3d5f4"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05982.x"},{"issue":"5","key":"17","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/0016-5085(94)90529-0","volume":"107","year":"1994","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2013\/494783.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2013\/494783.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2013\/494783.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T18:25:43Z","timestamp":1498069543000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/grp\/2013\/494783\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":17,"alternative-id":["494783","494783"],"URL":"https:\/\/doi.org\/10.1155\/2013\/494783","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}