{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:28:44Z","timestamp":1788870524079,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutics"],"published-print":{"date-parts":[[2013,4,4]]},"abstract":"<jats:p>\n                    The zalcitabine (ddC) has been extensively used in the treatment of HIV patients due to its antiretroviral activity. The quality control of this active principle in medications is of outstanding importance to public health. The principal objective of the current study was the development of an alternative analytical methodology for the zalcitabine determination using a voltammetric process. The zalcitabine gives a reduction peak (at\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mo>-<\/mml:mo>\n                      <mml:mn>1.22<\/mml:mn>\n                    <\/mml:math>\n                    \u2009V versus Ag\/AgCl) at the hanging mercury drop electrode (HMDE). The differential pulse voltammetric response is evaluated with respect to the scan rate (20\u2009mV\/s), pulse amplitude (50\u2009mV), support electrolyte (Clark-Lubs buffer), pH (2.0), and other variables. The response is linear over the 10.0 to 28.0\u2009mg\/L (47 to 133\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M) concentration range, and the detection limit is 2.08\u2009mg\/L. The validation of this method was realized using a governmental Brazilian document (Inmetro, 2007) and the results are reported for medication drugs.\n                  <\/jats:p>","DOI":"10.1155\/2013\/495814","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T18:28:42Z","timestamp":1365100122000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Determination of Zalcitabine in Medicaments by Differential Pulse Voltammetry"],"prefix":"10.1155","volume":"2013","author":[{"given":"Katia Christina","family":"Leandro","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josino Costa","family":"Moreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9rcio Augusto Mardini","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pontif\u00edcia Universidade Cat\u00f3lica, 225 Rua Marqu\u00eas de S\u00e3o Vicente, 22453-900 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(01)00167-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.02.009"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(98)80031-3"},{"key":"4","first-page":"629","volume-title":"Martindale","year":"1999"},{"issue":"8","key":"5","first-page":"604","volume":"59","year":"2004","journal-title":"Pharmazie"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.12.016"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/10826070701812715"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/10826070802711154"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.05.041"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/elan.200503307"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/00032711003687021"},{"issue":"1-2","key":"12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0022-0728(91)87040-B","volume":"316","year":"1991","journal-title":"Journal of Electroanalytical Chemistry"},{"key":"14","year":"1989","edition":"2"},{"issue":"1","key":"15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/1386207311107010022","volume":"14","year":"2011","journal-title":"Combinatorial Chemistry and High Throughput Screening"},{"issue":"9","key":"16","first-page":"1662","volume":"22","year":"2011","journal-title":"Journal of the Brazilian Chemical Society"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1149\/1.4704968","volume":"43","year":"2012","journal-title":"ECS Transactions"},{"issue":"3","key":"18","first-page":"133","volume":"2","year":"2012","journal-title":"Journal of Electrochemical Science and Engineering"}],"container-title":["Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/495814.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/495814.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/495814.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T22:28:15Z","timestamp":1644704895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jphar\/2013\/495814\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,4]]},"references-count":17,"alternative-id":["495814","495814"],"URL":"https:\/\/doi.org\/10.1155\/2013\/495814","relation":{},"ISSN":["2090-9918","2090-7818"],"issn-type":[{"value":"2090-9918","type":"print"},{"value":"2090-7818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,4]]}}}