{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:29:38Z","timestamp":1791872978282,"version":"4.3.4"},"reference-count":277,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,12,8]],"date-time":"2013-12-08T00:00:00Z","timestamp":1386460800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["102562"],"award-info":[{"award-number":["102562"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Inflammation"],"published-print":{"date-parts":[[2013,12,8]]},"abstract":"<jats:p>\n                    Oncostatin M is a secreted cytokine involved in homeostasis and in diseases involving chronic inflammation. It is a member of the gp130 family of cytokines that have pleiotropic functions in differentiation, cell proliferation, and hematopoetic, immunologic, and inflammatory networks. However, Oncostatin M also has activities novel to mediators of this cytokine family and others and may have fundamental roles in mechanisms of inflammation in pathology. Studies have explored Oncostatin M functions in cancer, bone metabolism, liver regeneration, and conditions with chronic inflammation including rheumatoid arthritis, lung and skin inflammatory disease, atherosclerosis, and cardiovascular disease. This paper will review Oncostatin M biology in a historical fashion and focus on its unique activities,\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , that differentiate it from other cytokines and inspire further study or consideration in therapeutic approaches.\n                  <\/jats:p>","DOI":"10.1155\/2013\/512103","type":"journal-article","created":{"date-parts":[[2013,12,8]],"date-time":"2013-12-08T16:01:34Z","timestamp":1386518494000},"page":"1-23","source":"Crossref","is-referenced-by-count":168,"title":["The Enigmatic Cytokine Oncostatin M and Roles in Disease"],"prefix":"10.1155","volume":"2013","author":[{"given":"Carl D.","family":"Richards","sequence":"first","affiliation":[{"name":"McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street, West, Hamilton, ON, Canada L8S 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