{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:42:55Z","timestamp":1790127775349,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"R & D Office of the Health and Personal Social Services Northern Ireland"},{"name":"Prostate Cancer Charity"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    The anaerobic skin commensal\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    is an underestimated cause of human infections and clinical conditions. Previous studies have suggested a role for the bacterium in lumbar disc herniation and infection. To further investigate this, five biopsy samples were surgically excised from each of 64 patients with lumbar disc herniation.\n                    <jats:italic>P. acnes<\/jats:italic>\n                    and other bacteria were detected by anaerobic culture, followed by biochemical and PCR-based identification. In total, 24\/64 (38%) patients had evidence of\n                    <jats:italic>P. acnes<\/jats:italic>\n                    in their excised herniated disc tissue. Using\n                    <jats:italic>recA<\/jats:italic>\n                    and mAb typing methods, 52% of the isolates were type II (50% of culture-positive patients), while type IA strains accounted for 28% of isolates (42% patients). Type III (11% isolates; 21% patients) and type IB strains (9% isolates; 17% patients) were detected less frequently. The MIC values for all isolates were lowest for amoxicillin, ciprofloxacin, erythromycin, rifampicin, tetracycline, and vancomycin (\u22641mg\/L). The MIC for fusidic acid was 1-2 mg\/L. The MIC for trimethoprim and gentamicin was 2 to \u22654\u2009mg\/L. The demonstration that type II and III strains, which are not frequently recovered from skin, predominated within our isolate collection (63%) suggests that the role of\n                    <jats:italic>P. acnes<\/jats:italic>\n                    in lumbar disc herniation should not be readily dismissed.\n                  <\/jats:p>","DOI":"10.1155\/2013\/530382","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T17:07:04Z","timestamp":1377709624000},"page":"1-7","source":"Crossref","is-referenced-by-count":64,"title":["Genotypic and Antimicrobial Characterisation of\n                    <i>Propionibacterium acnes<\/i>\n                    Isolates from Surgically Excised Lumbar Disc Herniations"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jess","family":"Rollason","sequence":"first","affiliation":[{"name":"The School of Health and Life Sciences, Department of Biomolecular Sciences, Coventry University, CV1 5FB, 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