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Events similar to those occurring in ER and in stress\u2010induced MH events are triggered after exposure to anesthetic agents in MH\u2010susceptible (MHS) patients. MH is an autosomal dominant hypermetabolic condition that occurs in genetically predisposed subjects during general anesthesia, induced by commonly used volatile anesthetics and\/or the neuromuscular blocking agent succinylcholine. Triggering agents cause an altered intracellular calcium regulation. Mutations in <jats:italic>RYR1<\/jats:italic> gene have been found in about 70% of MH families. The <jats:italic>RYR1<\/jats:italic> gene encodes the skeletal muscle calcium release channel of the sarcoplasmic reticulum, commonly known as ryanodine receptor type 1 (RYR1). The present work reviews the documented cases of ER or of stress\u2010induced MH events in which <jats:italic>RYR1<\/jats:italic> sequence variations, associated or possibly associated to MHS status, have been identified.<\/jats:p>","DOI":"10.1155\/2013\/531465","type":"journal-article","created":{"date-parts":[[2013,2,10]],"date-time":"2013-02-10T21:01:03Z","timestamp":1360530063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Exercise\u2010Induced Rhabdomyolysis and Stress\u2010Induced Malignant Hyperthermia Events, Association with Malignant Hyperthermia Susceptibility, and <i>RYR1<\/i> Gene Sequence 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