{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:39:55Z","timestamp":1792582795882,"version":"4.5.0"},"reference-count":44,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Recent reports of retinal stem cells being present in several locations of the adult eye have sparked great hopes that they may be used to treat the millions of people worldwide who suffer from blindness as a result of retinal disease or injury. A population of proliferative cells derived from the ciliary body epithelium (CE) has been considered one of the prime stem cell candidates, and as such they have received much attention in recent years. However, the true nature of these cells in the adult human eye has still not been fully elucidated, and the stem cell claim has become increasingly controversial in light of new and conflicting reports. In this paper, we will try to answer the question of whether the available evidence is strong enough for the research community to conclude that the adult human CE indeed harbors stem cells.<\/jats:p>","DOI":"10.1155\/2013\/531579","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T21:04:17Z","timestamp":1382994257000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["Does the Adult Human Ciliary Body Epithelium Contain \u201cTrue\u201d Retinal Stem Cells?"],"prefix":"10.1155","volume":"2013","author":[{"given":"Rebecca","family":"Fr\u00f8en","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Oslo University Hospital, Pb 4950 Nydalen, 0407 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik O.","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Oslo University Hospital, Pb 4950 Nydalen, 0407 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Nicolaissen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Oslo University Hospital, Pb 4950 Nydalen, 0407 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Facsk\u00f3","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Szeged, Kor\u00e1nyi fasor 10-11, Szeged 6720, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Szeged, Kor\u00e1nyi fasor 10-11, Szeged 6720, Hungary"},{"name":"Stem Cells and Eye Research Laboratory, Department of Biochemistry and Molecular Biology, Medical and Health Science Center and Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, University of Debrecen, Nagyerdei krt. 98, Debrecen 4032, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten C.","family":"Moe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Oslo University Hospital, Pb 4950 Nydalen, 0407 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"34","doi-asserted-by":"publisher","DOI":"10.1242\/dev.092270"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.2.3.265"},{"key":"31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.5661\/bger-26-297","volume":"26","year":"2009","journal-title":"Biotechnology and Genetic Engineering Reviews"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.02.001"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1089\/15258160360732713"},{"key":"33","series-title":"translated by R. M. Day from the 1913 Spanish edition","year":"1913"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.09.015"},{"key":"5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1874364101004010030","volume":"4","year":"2010","journal-title":"Open Journal of Ophthalmology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.04.005"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0724"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.11.018"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.05.002"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/1521-1878(200008)22:8&lt;685::AID-BIES1&gt;3.0.CO;2-C"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2473"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.2032"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1433"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-931-4_7"},{"issue":"5052","key":"36","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","volume":"255","year":"1992","journal-title":"Science"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1385\/MN:34:3:153"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7691"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7028"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250471697"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/nature04957"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.03.093"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth926"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901596106"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401596101"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.057687"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.118141"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1034"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/nn0502-392"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02198.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.03.008"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.09.020"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/stem.423"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1242\/bio.2012027"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2004.12.017"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0035"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh574"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/stem.279"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-012-9394-3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1797-3"},{"issue":"4","key":"41","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1634\/stemcells.20-4-279","volume":"20","year":"2002","journal-title":"Stem Cells"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.09.013"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/531579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/531579.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/531579.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:56:32Z","timestamp":1498092992000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/531579\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":44,"alternative-id":["531579","531579"],"URL":"https:\/\/doi.org\/10.1155\/2013\/531579","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}