{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:08:11Z","timestamp":1781626091664,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Inflammation"],"published-print":{"date-parts":[[2013,10,21]]},"abstract":"<jats:p>To study the ameliorating effects of curcumin in lipopolysaccharide (LPS) induced cardiac hypertrophy, mice were assigned to 4 groups (3 males and 3 females in each group): (A) control, (B) curcumin: 100\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg of body weight by intraperitoneal route (IP), (C) LPS: 60\u2009mg\/kg (IP), and (D) LPS + curcumin: both at previously stated concentrations by IP route. All mice were sacrificed as 12\u2009hr and 24\u2009hrs groups accordingly after LPS injection. The hearts were collected, photographed for cardiomegaly, and weighed to compare heart weight\/brain weight (HW\/BW) in mg\/mg. For immunohistochemistry, the tissue sections were exposed to histone H3, H4 and acetylated histone H3, H4 antibody. LPS induced a significant increase in histone acetylation as shown by intense staining. In curcumin + LPS treated mice nuclear staining was similar to the control group indicating that curcumin traversed the histone acetylation activity of the LPS. To further check the mechanism of action of curcumin, p300 protein acetylation levels were analyzed. This study suggests that the probable mechanism of action of curcumin is via the reduction of p300 HAT activity.<\/jats:p>","DOI":"10.1155\/2013\/539305","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T22:01:39Z","timestamp":1382392899000},"page":"1-8","source":"Crossref","is-referenced-by-count":17,"title":["Curcumin Attenuation of Lipopolysaccharide Induced Cardiac Hypertrophy in Rodents"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8514-1579","authenticated-orcid":true,"given":"Rupak","family":"Chowdhury","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-6603","authenticated-orcid":true,"given":"Ramadevi","family":"Nimmanapalli","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine, School of Pharmacy, Suwanee, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Graham","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Reddy","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"31","key":"1","first-page":"973","volume":"59","year":"2010","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"2","year":"2005\u20132013"},{"issue":"10","key":"3","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.4049\/jimmunol.165.10.5767","volume":"165","year":"2000","journal-title":"Journal of Immunology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000197782.21444.8f"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.06.017"},{"issue":"13","key":"7","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.114.13.2363","volume":"114","year":"2001","journal-title":"Journal of Cell Science"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.10.3593-3606.2003"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32865"},{"key":"10","first-page":"349","volume-title":"Curcumin derived from turmeric (Curcuma longa): a spice for all seasons","year":"2005"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.545"},{"key":"12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1097-4644(1999)75:32+<141::AID-JCB17>3.0.CO;2-A","volume":"75","year":"1999","journal-title":"Journal of Cellular Biochemistry"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319137"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.23.10180-10192.2004"},{"issue":"7\u20139","key":"15","first-page":"785","volume":"21","year":"2006","journal-title":"Histology and Histopathology"},{"issue":"3","key":"16","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1182\/blood.V95.3.745.003k05_745_755","volume":"95","year":"2000","journal-title":"Blood"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/365855a0"},{"issue":"8","key":"18","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1101\/gad.8.8.869","volume":"8","year":"1994","journal-title":"Genes and Development"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1021\/bi982409v"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2003.10.004"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409024200"}],"container-title":["ISRN Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/539305.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/539305.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/539305.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T20:32:42Z","timestamp":1646857962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2013\/539305\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,21]]},"references-count":20,"alternative-id":["539305","539305"],"URL":"https:\/\/doi.org\/10.1155\/2013\/539305","relation":{},"ISSN":["2090-8695"],"issn-type":[{"value":"2090-8695","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,21]]}}}