{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:15:53Z","timestamp":1791278153956,"version":"4.1.0"},"reference-count":15,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cancer Epidemiology"],"published-print":{"date-parts":[[2013]]},"abstract":"Background<\/jats:italic>. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation.Objective<\/jats:italic>. The purpose of the study was to compare the expression of vimentin in various histological grades of OSF.Materials and Methods<\/jats:italic>. To assess the immunohistochemical expression of vimentin in 20 mild cases of OSF, 20 severe cases of OSF, and ten cases of normal oral buccal mucosa.Results<\/jats:italic>. The overall staining intensity of vimentin significantly increased statistically (P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>) in OSF cases over normal control. A significant increase in the staining intensity of vimentin was also noted in the fibroblasts of severe cases of OSF (P<\/mml:mi>=<\/mml:mo>0.03<\/mml:mn><\/mml:math>).Conclusion<\/jats:italic>. Considering the marked vimentin expression in the present study, future studies should include cytoskeleton IF and other filaments in the fibroblasts of OSF.<\/jats:p>","DOI":"10.1155\/2013\/549041","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T21:01:45Z","timestamp":1370984505000},"page":"1-6","source":"Crossref","is-referenced-by-count":15,"title":["Immunohistochemical Analysis of Vimentin in Oral Submucous Fibrosis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Meghanand T.","family":"Nayak","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology, Vyas Dental College and Hospital, Jodhpur, Rajasthan 342011, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine & Radiology, Vyas Dental College and Hospital, Jodhpur 342011, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology, Nair Hospital Dental College, Mumbai 400008, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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