{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:45:24Z","timestamp":1788871524435,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U54 CK000163"],"award-info":[{"award-number":["U54 CK000163"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis Research and Treatment"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : our objective was to determine the incidence of toxicity among veterans initiating isoniazid therapy for latent tuberculosis infection (LTBI) and determine whether advancing age was a risk factor for toxicity.\n                    <jats:italic>Methods<\/jats:italic>\n                    : we performed a retrospective cohort study among all adults initiating isoniazid treatment for LTBI at a Veterans Medical Center from 1999 to 2005. We collected data on patient demographics, co-morbidities, site of initiation, and treatment outcome.\n                    <jats:italic>Results<\/jats:italic>\n                    : 219 patients initiated isoniazid therapy for LTBI during the period of observation, and the completion of therapy was confirmed in 100 patients (46%). Among 18\/219 patients (8%) that discontinued therapy due to a documented suspected toxicity, the median time to onset was 3 months (IQR 1\u20135 months). In an adjusted Cox regression model, there was no association between discontinuation due to suspected toxicity and advancing age (HR 1.03, 95% CI 0.99, 1.07). In contrast, hepatitis C infection was a significant predictor of cessation due to toxicity in the adjusted analysis (HR 3.03, 95% CI 1.08, 8.52).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : cessation of isoniazid therapy due to suspected toxicity was infrequently observed among a veteran population and was not associated with advancing age. Alternative LTBI treatment approaches should be further examined in the veteran population.\n                  <\/jats:p>","DOI":"10.1155\/2013\/549473","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T16:27:48Z","timestamp":1357835268000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Isoniazid Toxicity among an Older Veteran Population: A Retrospective Cohort Study"],"prefix":"10.1155","volume":"2013","author":[{"given":"Christopher","family":"Vinnard","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine, College of Medicine, Drexel University, 245 N. 15th Street MS 461, New College Building 6314, Philadelphia, PA 19102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Gopal","sequence":"additional","affiliation":[{"name":"College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren R.","family":"Linkin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"},{"name":"Department of Medicine, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Maslow","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Morristown Medical Center, Morristown, NJ 07962, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.7.677"},{"issue":"s221","key":"2","volume":"161","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"6","key":"3","first-page":"991","volume":"117","year":"1978","journal-title":"American Review of Respiratory Disease"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200303-390OC"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X80387"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.1.116"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1086\/422645"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.11.1014"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1086\/314037"},{"key":"10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1086\/345906","volume":"36","year":"2003","journal-title":"Clinical Infectious Diseases"},{"issue":"11","key":"11","first-page":"1374","volume":"14","year":"2010","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1378\/chest.108.3.706","volume":"108","year":"1995","journal-title":"Chest"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1086\/502350"},{"key":"14","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.7205\/MILMED-D-11-00141","volume":"176","year":"2011","journal-title":"Military Medicine"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.17.1863"},{"issue":"8","key":"16","doi-asserted-by":"crossref","first-page":"640","DOI":"10.7326\/0003-4819-137-8-200210150-00007","volume":"137","year":"2002","journal-title":"Annals of Internal Medicine"}],"container-title":["Tuberculosis Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2013\/549473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2013\/549473.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2013\/549473.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T01:29:56Z","timestamp":1498008596000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/trt\/2013\/549473\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"alternative-id":["549473","549473"],"URL":"https:\/\/doi.org\/10.1155\/2013\/549473","relation":{},"ISSN":["2090-150X","2090-1518"],"issn-type":[{"value":"2090-150X","type":"print"},{"value":"2090-1518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}