{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:31:16Z","timestamp":1768289476772,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Autoimmune hepatitis (AIH) is occasionally triggered by drug treatments. Recently, as biological agents are becoming widely used for autoimmune disorders, there have been a growing number of reports of the development of autoimmune processes related to these agents. A 52-year-old Japanese woman with psoriasis developed liver damage two months after initiation of anti-TNF-<jats:italic>\u03b1<\/jats:italic>therapy with adalimumab. Liver histological findings were compatible with AIH, and positive conversions of ANAs were detected. The patient was treated with prednisolone and had a good response. While some cases of AIH triggered by anti-TNF-<jats:italic>\u03b1<\/jats:italic>therapies have been reported, the pathogenesis remains unspecified. When elevation of liver enzymes is observed with high IgG levels and seropositivity of ANA during the course of anti-TNF-<jats:italic>\u03b1<\/jats:italic>therapy, liver biopsy findings may be essential and important to make definitive diagnosis of AIH.<\/jats:p>","DOI":"10.1155\/2013\/561748","type":"journal-article","created":{"date-parts":[[2013,9,8]],"date-time":"2013-09-08T17:01:06Z","timestamp":1378659666000},"page":"1-3","source":"Crossref","is-referenced-by-count":12,"title":["Autoimmune Hepatitis Triggered by Anti-TNF- Therapy"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-1961","authenticated-orcid":true,"given":"Satoshi","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Mishuku Hospital, 5-33-12, Kamimeguro, Meguro-ku, Tokyo 153-0051, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23588"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.10.003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1191-4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.032821"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03088.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.02.029"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181a745e7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12054"},{"key":"10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.autrev.2012.03.010","volume":"12","year":"2013","journal-title":"Autoimmunity Reviews"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328350f95b"},{"key":"12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.clim.2012.10.008","volume":"146","year":"2013","journal-title":"Clinical Immunology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.433"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1748-1"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2013\/561748.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2013\/561748.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2013\/561748.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T17:33:37Z","timestamp":1498066417000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crim\/2013\/561748\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":13,"alternative-id":["561748","561748"],"URL":"https:\/\/doi.org\/10.1155\/2013\/561748","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}