{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:15:40Z","timestamp":1788869740367,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T00:00:00Z","timestamp":1377302400000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200136"],"award-info":[{"award-number":["81200136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    <jats:italic>Backgrounds<\/jats:italic>\n                    . Segmental and circumferential pulmonary vein isolations (SPVI and CPVI) have been demonstrated to be effective therapies for paroxysmal atrial fibrillation (PAF). PVI is well established as the endpoint of different ablation techniques, whereas it may not completely account for the long\u2010term success.\n                    <jats:italic>Methods<\/jats:italic>\n                    . 181 drug\u2010refractory symptomatic PAF patients were referred for segmental or circumferential PVI (SPVI\u2009=\u200967; CPVI\u2009=\u2009114). Heart rate variability (HRV) was assessed before and after the final ablation.\n                    <jats:italic>Results<\/jats:italic>\n                    . After following up for 62.23 \u00b1 12.75 months, patients underwent 1.41 \u00b1 0.68 procedures in average, and the success rates in SPVI and CPVI groups were comparable. 119 patients were free from AF recurrence (SPVI\u2010S,\n                    <jats:italic>n<\/jats:italic>\n                    = 43; CPVI\u2010S,\n                    <jats:italic>n<\/jats:italic>\n                    = 76). 56 patients had recurrent episodes (SPVI\u2010R,\n                    <jats:italic>n<\/jats:italic>\n                    = 21; CPVI\u2010R,\n                    <jats:italic>n<\/jats:italic>\n                    = 35). Either ablation technique decreased HRV significantly. Postablation SDNN and rMSSD were significantly lower in SPVI\u2010S and CPVI\u2010S subgroups than in SPVI\u2010R and CPVI\u2010R subgroups (SPVI\u2010S versus SPVI\u2010R: SDNN 91.8 \u00b1 32.6 versus 111.5 \u00b1 36.2\u2009ms, rMSSD 47.4 \u00b1 32.3 versus 55.2 \u00b1 35.2\u2009ms; CPVI\u2010S versus CPVI\u2010R: SDNN 83.0 \u00b1 35.6 versus 101.0 \u00b1 40.7\u2009ms, rMSSD 41.1 \u00b1 22.9 versus 59.2 \u00b1 44.8\u2009ms; all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Attenuation of SDNN and rMSSD remained for 12 months in SPVI\u2010S and CPVI\u2010S subgroups, whereas it recovered earlier in SPVI\u2010R and CPVI\u2010R subgroups. Multivariate logistic regression analysis identified SDNN as the only predictor of long\u2010term success.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Beyond PVI, denervation may be a common mechanism underlying different ablation strategies for PAF.\n                  <\/jats:p>","DOI":"10.1155\/2013\/569564","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T17:01:53Z","timestamp":1377363713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Denervation as a Common Mechanism Underlying Different Pulmonary Vein Isolation Strategies for Paroxysmal Atrial Fibrillation: Evidenced by Heart Rate Variability after 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