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Systemic coinoculation of prediabetic mice with recombinant vaccinia virus rVV-CTB::GAD and undiluted or 10-fold diluted CFA demonstrated a significant decrease in hyperglycemia and pancreatic islet inflammation in comparison with control animals during 17\u201361 and 17\u2013105 weeks of age, respectively. Synergy in these beneficial effects was observed during 43\u201361 and 61\u2013105 wks of age, respectively. Inflammatory cytokine and chemokine levels in GAD-stimulated splenocytes isolated from vaccinated mice were generally lower than those detected in unvaccinated mice. The overall health and humoral immune responses of the vaccinated animals remained normal throughout the duration of the experiments.<\/jats:p>","DOI":"10.1155\/2013\/578786","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T21:01:08Z","timestamp":1384203668000},"page":"1-16","source":"Crossref","is-referenced-by-count":6,"title":["Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund\u2019s Adjuvant"],"prefix":"10.1155","volume":"2013","author":[{"given":"B\u00e9la","family":"D\u00e9nes","sequence":"first","affiliation":[{"name":"Center for Health Disparities and Molecular Medicine, Department of Biochemistry, School of Medicine, Loma Linda University, 11085 Campus Street, Loma Linda, CA 92350, USA"},{"name":"Department of Immunology, Central Veterinary Institute, T\u00e1bornok u. 2, 1143 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Fodor","sequence":"additional","affiliation":[{"name":"Center for Health Disparities and Molecular Medicine, Department of Biochemistry, School of Medicine, Loma Linda University, 11085 Campus Street, Loma Linda, CA 92350, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H. 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