{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:01:13Z","timestamp":1791212473557,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    Ehlers-Danlos syndrome hypermobility type a. k. a. joint hypermobility syndrome (JHS\/EDS-HT) is a hereditary musculoskeletal disorder associating generalized joint hypermobility with chronic pain. Anecdotal reports suggest a prominent role for\n                    <jats:italic>kinesiophobia<\/jats:italic>\n                    in disease manifestations, but no study has systematically addressed this point.\n                    <jats:italic>Objective<\/jats:italic>\n                    . To investigate the impact of\n                    <jats:italic>kinesiophobia<\/jats:italic>\n                    and its relationship with pain, fatigue, and quality of life in JHS\/EDS-HT.\n                    <jats:italic>Design<\/jats:italic>\n                    . Cross-sectional study.\n                    <jats:italic>Subjects\/Patients<\/jats:italic>\n                    . 42 patients (40 female and 2 male) with JHS\/EDS-HT diagnosis following standardized diagnostic criteria were selected.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Disease features were analyzed by means of specific questionnaires and scales evaluating kinesiophobia, pain, fatigue, and quality of life. The relationships among variables were investigated using the Spearman bivariate analysis.\n                    <jats:italic>Results<\/jats:italic>\n                    .\n                    <jats:italic>Kinesiophobia<\/jats:italic>\n                    resulted predominantly in the patients\u2019 sample. The values of\n                    <jats:italic>kinesiophobia<\/jats:italic>\n                    did not correlate with intensity of pain, quality of life, and (or) the single component of fatigue. A strong correlation was discovered between\n                    <jats:italic>kinesiophobia<\/jats:italic>\n                    and general severity of fatigue.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . In JHS\/EDS-HT, the onset of pain-avoiding strategies is related to the presence of pain but not to its intensity. The clear-cut correlation between\n                    <jats:italic>kinesiophobia<\/jats:italic>\n                    and severity of fatigue suggests a direct link between musculoskeletal pain and fatigue. In JHS\/EDS-HT, the underlying mechanism is likely to be facilitated by primary disease characteristics, including hypotonia.\n                  <\/jats:p>","DOI":"10.1155\/2013\/580460","type":"journal-article","created":{"date-parts":[[2013,7,14]],"date-time":"2013-07-14T17:02:14Z","timestamp":1373821334000},"page":"1-7","source":"Crossref","is-referenced-by-count":71,"title":["Evaluation of Kinesiophobia and Its Correlations with Pain and Fatigue in Joint Hypermobility Syndrome\/Ehlers-Danlos Syndrome Hypermobility Type"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-5882","authenticated-orcid":true,"given":"Claudia","family":"Celletti","sequence":"first","affiliation":[{"name":"Physical Medicine and Rehabilitation, Department of Orthopaedics, Sapienza University, Umberto I Hospital, Piazzale Aldo Moro 3, 00185 Rome, 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