{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:21Z","timestamp":1791404901735,"version":"4.3.3"},"reference-count":44,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"European Community","award":["FP7-HEALTH-2010-243121"],"award-info":[{"award-number":["FP7-HEALTH-2010-243121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Filariae are a leading cause of infections which are responsible for serious dermatological, ocular, and vascular lesions. Infective third stage larvae (L3) are transmitted through the bite of a haematophagous vector.<jats:italic>Litomosoides sigmodontis<\/jats:italic>is a well-established model of filariasis in the mouse, with the vector being the mite<jats:italic>Ornithonyssus bacoti<\/jats:italic>. The aim of the study was to analyse the filarial infection in mites to determine the consequences of filarial infection in the blood-feeding and the reproduction of mites as well as in the regulation of vector-induced inflammation in the mouse skin. Firstly, L3 are unevenly distributed throughout the host population and the majority of the population harbours a moderate infection (1 to 6 L3). Filarial infection does not significantly affect the probing delay for blood feeding. The number of released protonymphs is lower in infected mites but is not correlated with the L3 burden. Finally, induced excreted proteins from infected mites but not from uninfected mites stimulate TNF-<jats:italic>\u03b1<\/jats:italic>and the neutrophil-chemoattractant KC production by antigen-presenting cells (APCs). Altogether, these results describe the modification of the mite behavior under filarial infection and suggest that the immunomodulatory capacity of the mite may be modified by the presence of the parasite, hindering its defensive ability towards the vertebrate host.<\/jats:p>","DOI":"10.1155\/2013\/584105","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T21:44:31Z","timestamp":1378763071000},"page":"1-8","source":"Crossref","is-referenced-by-count":13,"title":["Fitness Cost of<i>Litomosoides sigmodontis<\/i>Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ad\u00e9la\u00efde","family":"Nieguitsila","sequence":"first","affiliation":[{"name":"UMR 7245 MCAM MNHN CNRS, Mus\u00e9um National d\u2019Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, France"},{"name":"UMR 5554 ISEM CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Frutos","sequence":"additional","affiliation":[{"name":"UMR 5236 Centre d'\u00c9tudes d'Agents Pathog\u00e8nes et Biotechnologies pour la Sant\u00e9 (CPBS), 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Moulia","sequence":"additional","affiliation":[{"name":"UMR 5554 ISEM CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaly","family":"Lhermitte-Vallarino","sequence":"additional","affiliation":[{"name":"UMR 7245 MCAM MNHN CNRS, Mus\u00e9um National d\u2019Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Bain","sequence":"additional","affiliation":[{"name":"UMR 7245 MCAM MNHN CNRS, Mus\u00e9um National d\u2019Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Gavotte","sequence":"additional","affiliation":[{"name":"UMR 5554 ISEM CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Martin","sequence":"additional","affiliation":[{"name":"UMR 7245 MCAM MNHN CNRS, Mus\u00e9um National d\u2019Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/1469-0691.12069","volume":"19","year":"2013","journal-title":"Clinical Microbiology and Infectious Deseases"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000217"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1051\/parasite\/1992675144","volume":"67","year":"1992","journal-title":"Annales de Parasitologie Humaine et Comparee"},{"issue":"6","key":"4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/BF00925099","volume":"72","year":"1986","journal-title":"Zeitschrift fur Parasitenkunde"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1051\/parasite\/1990654193","volume":"65","year":"1990","journal-title":"Annales de Parasitologie Humaine et Comparee"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1086\/515016","volume":"27","year":"1998","journal-title":"Clinical Infectious Diseases"},{"issue":"4","key":"7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2307\/3273464","volume":"36","year":"1950","journal-title":"The Journal of Parasitology"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0014-4894(53)90016-2","volume":"2","year":"1953","journal-title":"Experimental Parasitology"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2307\/3281507","volume":"72","year":"1986","journal-title":"The Journal of Parasitology"},{"issue":"6","key":"10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1051\/parasite\/1989646478","volume":"64","year":"1989","journal-title":"Annales de Parasitologie Humaine et Comparee"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/00034983.1950.11685451","volume":"44","year":"1950","journal-title":"Annals of Tropical Medecine and Parasitology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2010.0197"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-077X(04)90007-8"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.73"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00482-10"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.12.6704"},{"key":"17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.en.41.010196.000245","volume":"41","year":"1996","journal-title":"Annual Review of Entomology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(94)90173-2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.06.032"},{"issue":"1","key":"20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","year":"1985","journal-title":"Analytical Biochemistry"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.54.110807.090626"},{"key":"22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1051\/parasite\/1971465613","volume":"46","year":"1971","journal-title":"Annale de Parasitologie Humaine et Compar\u00e9e"},{"key":"23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1051\/parasite\/1976511095","volume":"51","year":"1976","journal-title":"Annale de Parasitologie Humaine et Compar\u00e9e"},{"issue":"4","key":"24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S0031182000064751","volume":"110","year":"1995","journal-title":"Parasitology"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.2006.00629.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.09.001"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.0269-283X.2005.00549.x"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.48.091801.112722"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(98)01224-1"},{"issue":"4","key":"30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.4269\/ajtmh.1992.47.484","volume":"47","year":"1992","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"issue":"4","key":"31","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/jmedent\/33.4.516","volume":"33","year":"1996","journal-title":"Journal of Medical Entomology"},{"issue":"3","key":"32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0035-9203(00)90349-3","volume":"94","year":"2000","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"issue":"2","key":"33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4269\/ajtmh.1986.35.277","volume":"35","year":"1986","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"34","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1179\/000349802125002509","volume":"96","year":"2002","journal-title":"Annals of Tropical Medicine and Parasitology"},{"issue":"3","key":"35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1051\/parasite\/1994013241","volume":"1","year":"1994","journal-title":"Parasite"},{"issue":"12","key":"36","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1046\/j.1365-3156.1997.d01-218.x","volume":"2","year":"1997","journal-title":"Tropical Medicine and International Health"},{"key":"37","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.en.32.010187.002335","volume":"32","year":"1987","journal-title":"Annual Review of Entomology"},{"issue":"3","key":"38","first-page":"143","volume":"4","year":"1995","journal-title":"Infectious Agents and Disease"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004005189"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.02079.x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072689"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000612"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00263-2"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/719361"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/584105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/584105.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/584105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T19:48:48Z","timestamp":1563911328000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/584105\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":44,"alternative-id":["584105","584105"],"URL":"https:\/\/doi.org\/10.1155\/2013\/584105","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}