{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:53:31Z","timestamp":1763535211031,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>We assessed the associations between the<jats:italic>APOA5<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mo>\u2009\u2009\u2212<\/mml:mo><\/mml:mrow><\/mml:math>1131T<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>C polymorphism and lipid parameters and other risk factors of the metabolic syndrome in Korean subjects. A total of 2,901 participants from 20 oriental medical hospitals in Korea were enrolled between 2006 and 2011. According to the modified National Cholesterol Education Program Adult Treatment Panel III definitions, subjects were classified into the metabolic syndrome group and control group. The<jats:italic>APOA5<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mo>\u2009\u2009\u2212<\/mml:mo><\/mml:mrow><\/mml:math>1131T<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>C genotype was significantly associated with serum high-density lipoprotein cholesterol levels (effect = \u2212\u20091.700\u2009mg\/dL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P=6.550<\/mml:mi><\/mml:mrow><\/mml:math>-E07) in the total study population after adjustment for differences in age and gender. The association of the<jats:italic>APOA5<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mo>\u2009\u2009\u2212<\/mml:mo><\/mml:mrow><\/mml:math>1131T<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>C genotype with serum log-transformed triglyceride was also significant in an additive genetic model (effect = 0.056\u2009mg\/dL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mrow><mml:mi>P=2.286<\/mml:mi><\/mml:mrow><\/mml:math>E-19). After adjustment for age and gender, we determined that the odds ratio for the occurrence of the metabolic syndrome was 1.322 for C-allele carriers in the additive model (95% CI = [1.165 \u2212 1.501],<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mrow><mml:mi>P=1.48<\/mml:mi><\/mml:mrow><\/mml:math>E-05). In the current study, we demonstrated that the<jats:italic>APOA5<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mrow><mml:mo>\u2009\u2009\u2212<\/mml:mo><\/mml:mrow><\/mml:math>1131T<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>C polymorphism is associated with the metabolic syndrome because of its remarkable effect on serum triglyceride levels in Korean subjects.<\/jats:p>","DOI":"10.1155\/2013\/585134","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T23:49:20Z","timestamp":1359416960000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Association of Apolipoprotein A5 Gene<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo>\u2009\u2009\u2212<\/mml:mo><\/mml:mrow><\/mml:math>1131T<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>C Polymorphism with the Risk of Metabolic Syndrome in Korean Subjects"],"prefix":"10.1155","volume":"2013","author":[{"given":"Kwang Hoon","family":"Song","sequence":"first","affiliation":[{"name":"Division of Constitutional Medicine Research, and Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 483 Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongwon","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Constitutional Medicine Research, and Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 483 Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Gon","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Constitutional Medicine Research, and Herbal Medicine Research 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