{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:11:08Z","timestamp":1774282268905,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["C-24592616"],"award-info":[{"award-number":["C-24592616"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP).<jats:italic>Methods<\/jats:italic>. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2\u00b0 (\u0394CENT4).<jats:italic>Results<\/jats:italic>. The mean MD slopes were \u22120.55\/\u22120.39 (right\/left eyes,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>19<\/mml:mn><\/mml:mrow><\/mml:math>) dB\/year in the treated group and \u22121.37\/\u22121.15 (right\/left eyes,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>22<\/mml:mn><\/mml:mrow><\/mml:math>) dB\/year in the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.016<\/mml:mn><mml:mo>\/<\/mml:mo><mml:mn>0.050<\/mml:mn><\/mml:mrow><\/mml:math>, resp.). In both eyes, however, no statistical difference was observed between the two groups for the \u0394CENT4 values.<jats:italic>Conclusion<\/jats:italic>. Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10\u00b0, it was not specific for the central 2\u00b0 of the visual field in RP.<\/jats:p>","DOI":"10.1155\/2013\/585729","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T16:10:56Z","timestamp":1384272656000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study"],"prefix":"10.1155","volume":"2013","author":[{"given":"Mitsuru","family":"Nakazawa","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Metoki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohguro","sequence":"additional","affiliation":[{"name":"Department 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