{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:34:07Z","timestamp":1762659247298,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>This study analyzed the effects of a low-level laser therapy (LLLT, 15\u2009J\/cm<jats:sup>2<\/jats:sup>, 780\u2009nm wavelength) and the natural latex protein (P1, 0.1%) in sciatic nerve after crush injury (15\u2009Kgf, axonotmesis) in rats. Sixty rats (male, 250\u2009g) were allocated into the 6 groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:mrow><\/mml:math>): CG\u2014control group; EG\u2014nerve exposed; IG\u2014injured nerve without treatment; LG\u2014crushed nerve treated with LLLT; PG\u2014injured nerve treated with P1; and LPG\u2014injured nerve treated with LLLT and P1. After 4 or 8 weeks, the nerve samples were processed for morphological, histological quantification and ultrastructural analysis. After 4 weeks, the myelin density and morphological characteristics improved in groups LG, PG, and LPG compared to IG. After 8 weeks, PG, and LPG were similar to CG and the capillary density was higher in the LG, PG, and LPG. In the ultrastructural analysis the PG and LPG had characteristics that were similar to the CG. The application of LLLT and\/or P1 improved the recovery from the nerve crush injury, and in the long term, the P1 protein was the better treatment used, since only the application of LLLT has not reached the same results, and these treatments applied together did not potentiate the recovery.<\/jats:p>","DOI":"10.1155\/2013\/597863","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T21:01:55Z","timestamp":1372798915000},"page":"1-11","source":"Crossref","is-referenced-by-count":10,"title":["Application of a Low-Level Laser Therapy and the Purified Protein from Natural Latex (<i>Hevea brasiliensis<\/i>) in the Controlled Crush Injury of the Sciatic Nerve of Rats: A Morphological, Quantitative, and Ultrastructural Study"],"prefix":"10.1155","volume":"2013","author":[{"given":"Fernando Jos\u00e9","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, 2415 Avenida 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