{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:34:29Z","timestamp":1789436069653,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006374","name":"Universitas Brawijaya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Microbiology"],"published-print":{"date-parts":[[2013,8,29]]},"abstract":"<jats:p>\n                    Typhoid fever is a disease caused by\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhi and commonly treated by an antimicrobial agent such as cotrimoxazole. On the other hand, herbal usage has risen as an adjunctive therapy to treat many diseases.\n                    <jats:italic>Curcuma<\/jats:italic>\n                    (\n                    <jats:italic>Curcuma domestica<\/jats:italic>\n                    ) is a commonly used herb which consists of curcumin as its major active compound. Curcumin has been known for its antimicrobial effect, but there is no proof regarding the usage of curcumin and cotrimoxazole together. This research was conducted by using typhoid fever model in mice infected by\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium. Each animal was treated with curcumin, cotrimoxazole, or both. Ileum, spleen, and liver of each animal were isolated and cultured. We found that curcumin-cotrimoxazole combination therapy lowered the antimicrobial effectivity of cotrimoxazole in both intraintestinal and extraintestinal organs. We conclude that curcumin-cotrimoxazole combination therapy in typhoid fever has to be reconsidered.\n                  <\/jats:p>","DOI":"10.1155\/2013\/601076","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T17:01:31Z","timestamp":1377795691000},"page":"1-4","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Curcumin and Cotrimoxazole in\n                    <i>Salmonella<\/i>\n                    Typhimurium Infection In Vivo"],"prefix":"10.1155","volume":"2013","author":[{"given":"Siwipeni Irmawanti","family":"Rahayu","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Faculty of Medicine, Brawijaya University, Jl Veteran Malang 65145, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdiana","family":"Nurdiana","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine, Brawijaya University, Jl Veteran Malang 65145, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanarto","family":"Santoso","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Faculty of Medicine, Brawijaya University, Jl Veteran Malang 65145, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"2","year":"2012"},{"key":"3","first-page":"584","volume-title":"Sulfonamid, Kotrimoksazol dan Antiseptik Saluran Kemih","year":"1995"},{"key":"4","year":"2010"},{"key":"5","year":"2012"},{"issue":"21","key":"6","first-page":"3832","volume":"7","year":"2008","journal-title":"African Journal of Biotechnology"},{"issue":"12","key":"7","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.4049\/jimmunol.168.12.6396","volume":"168","year":"2002","journal-title":"Journal of Immunology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705241"},{"key":"9","year":"2009"},{"key":"10","series-title":"Enterobacteriaceae","year":"1994"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.1.1-12.2003"},{"key":"12","series-title":"Advances in Molecular and Cellular Microbiology","volume":"1\u20133","year":"2004"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/00365540310015629"},{"key":"14","year":"2006"},{"issue":"2","key":"15","first-page":"141","volume":"14","year":"2009","journal-title":"Alternative Medicine Review"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks375"}],"container-title":["ISRN Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/601076.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/601076.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/601076.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T06:13:26Z","timestamp":1607580806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2013\/601076\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":15,"alternative-id":["601076","601076"],"URL":"https:\/\/doi.org\/10.1155\/2013\/601076","relation":{},"ISSN":["2090-7486"],"issn-type":[{"value":"2090-7486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}