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Genetic studies have provided an opportunity to determine which proteins link vitamin D to PBC pathology (e.g., the major histocompatibility complex class II molecules, the vitamin D receptor, toll-like receptors, apolipoprotein E,<jats:italic>Nramp1<\/jats:italic>, and cytotoxic T lymphocyte antigen-4). Vitamin D also exerts its effect on PBC through cell signaling mechanisms, that is, matrix metalloproteinases, prostaglandins, reactive oxygen species, and the transforming growth factor betas. In conclusion, vitamin D may have a beneficial role in the treatment of PBC. The best form of vitamin D for use in the PBC is calcitriol because it is the active form of vitamin metabolite, and its receptors are present in the sinusoidal endothelial cells, Kupffer cells, and stellate cells of normal livers, as well as in the biliary cell line.<\/jats:p>","DOI":"10.1155\/2013\/602321","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T21:07:13Z","timestamp":1364332033000},"page":"1-12","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Vitamin D in Primary Biliary Cirrhosis: Possible Genetic and Cell Signaling Mechanisms"],"prefix":"10.1155","volume":"2013","author":[{"given":"Khanh vinh qu\u1ed1c","family":"L\u01b0\u01a1ng","sequence":"first","affiliation":[{"name":"Vietnamese American Medical Research Foundation, 14971 Brookhurst Street, Westminster, CA 92683, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan Thi 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