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The major pathogens of neonatal sepsis, group B Streptococci,<jats:italic>Escherichia coli<\/jats:italic>,<jats:italic>Listeria monocytogenes<\/jats:italic>, and<jats:italic>Staphylococcus aureus<\/jats:italic>, secrete toxins of different molecular nature, which are key for defining the disease. Amongst these toxins are pore-forming exotoxins that are expressed as soluble monomers prior to engagement of the target cell membrane with subsequent formation of an aqueous membrane pore. Membrane pore formation is not only a means for immediate lysis of the targeted cell but also a general mechanism that contributes to penetration of epithelial barriers and evasion of the immune system, thus creating survival niches for the pathogens. Pore-forming toxins, however, can also contribute to the induction of inflammation and hence to the manifestation of sepsis. 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