{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:55:51Z","timestamp":1784652951491,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado da Bahia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Lippia origanoides<\/jats:italic>Kunth,<jats:italic>Lippia alnifolia<\/jats:italic>Schauer, and<jats:italic>Lippia thymoides<\/jats:italic>Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine.<jats:italic>L. origanoides<\/jats:italic>leaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation of<jats:italic>L. origanoides<\/jats:italic>crude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate that<jats:italic>L. origanoides<\/jats:italic>may be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs.<\/jats:p>","DOI":"10.1155\/2013\/614501","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T05:18:50Z","timestamp":1378876730000},"page":"1-5","source":"Crossref","is-referenced-by-count":19,"title":["Antimicrobial Activity of<i>Lippia<\/i>Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents"],"prefix":"10.1155","volume":"2013","author":[{"given":"Cristiana da Purifica\u00e7\u00e3o","family":"Pinto","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais e Bioativos, Departamento de Ci\u00eancias Exatas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velize Dias","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais e Bioativos, Departamento de Ci\u00eancias Exatas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda da Purifica\u00e7\u00e3o","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais e Bioativos, Departamento de Ci\u00eancias Exatas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata da Purifica\u00e7\u00e3o","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais e Bioativos, Departamento de Ci\u00eancias Exatas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Trovatti","family":"Uetanabaro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia da Agroind\u00fastria, Universidade Estadual de Santa Cruz, Campus Soane Nazar\u00e9 de Andrade, Km 16 Rodovia Ilh\u00e9us-Itabuna, 45662-900 Ilh\u00e9us, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Santos Ribeiro","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana Ferreira Magalh\u00e3es","family":"Gadea","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia Regina dos Santos","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Maria","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais e Bioativos, Departamento de Ci\u00eancias Exatas, Universidade Estadual de Feira de Santana, Avenida Transnordestina S\/N, Bairro Novo Horizonte, Campus Universit\u00e1rio, 44036-900 Feira de Santana, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"2012"},{"issue":"25","key":"2","first-page":"2886","volume":"6","year":"2007","journal-title":"African Journal of Biotechnology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.07.048"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.07.070"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00234-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.01.022"},{"key":"7","year":"2004"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2008000300023"},{"issue":"5","key":"9","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/10412905.2004.9698782","volume":"16","year":"2004","journal-title":"Journal of Essential Oil Research"},{"issue":"4","key":"10","first-page":"313","volume":"17","year":"2009","journal-title":"Ciencia"},{"issue":"13","key":"11","first-page":"160","volume":"15","year":"2011","journal-title":"Infection"},{"key":"12","year":"2003"},{"key":"13","year":"2003"},{"key":"14","year":"2002"},{"key":"15","year":"1984"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.19.5709-5717.2001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05872.x"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1590\/S1517-83822007000200034","volume":"38","year":"2007","journal-title":"Brazilian Journal of Microbiology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"issue":"4","key":"20","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.12.4.564","volume":"12","year":"1999","journal-title":"Clinical Microbiology Reviews"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/614501.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/614501.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/614501.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T18:28:37Z","timestamp":1563906517000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/614501\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":20,"alternative-id":["614501","614501"],"URL":"https:\/\/doi.org\/10.1155\/2013\/614501","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}