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A mechanism for resistance has been proposed in which methicillin resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(MRSA) isolates acquired a new protein called<jats:italic>\u03b2<\/jats:italic>-lactam inducible penicillin binding protein (PBP-2\u2032). The PBP-2\u2032 functions by substituting other penicillin binding proteins which have been inhibited by<jats:italic>\u03b2<\/jats:italic>-lactam antibiotics. Presently, there is no structural and regulatory information on PBP-2\u2032 protein. We conducted a complete structural and functional regulatory analysis of PBP-2\u2032 protein. Our analysis revealed that the PBP-2\u2032 is very stable with more hydrophilic amino acids expressing antigenic sites. PBP-2\u2032 has three striking regulatory points constituted by first penicillin binding site at Ser25, second penicillin binding site at Ser405, and finally a single metallic ligand binding site at Glu657 which binds to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mtext mathvariant=\"normal\">Z<\/mml:mtext><mml:mtext mathvariant=\"normal\">n<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>ions. This report highlights structural features of PBP-2\u2032 that can serve as targets for developing new chemotherapeutic agents and conducting site direct mutagenesis experiments.<\/jats:p>","DOI":"10.1155\/2013\/614670","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T21:03:21Z","timestamp":1375131801000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Functional Regulatory Residues of the<b><i>\u03b2<\/i><\/b>-Lactam Inducible Penicillin Binding Protein in Methicillin-Resistant<i>Staphylococcus aureus<\/i>"],"prefix":"10.1155","volume":"2013","author":[{"given":"Andreas N.","family":"Mbah","sequence":"first","affiliation":[{"name":"Center for Bioinformatics & Computational Biology, Department of Biology, Jackson State University, Jackson, MS 39217, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael D.","family":"Isokpehi","sequence":"additional","affiliation":[{"name":"Center for 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