{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:13:20Z","timestamp":1740165200576,"version":"3.37.3"},"reference-count":3,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To present a case of<jats:italic>Drechslera<\/jats:italic>spp. keratitis treated with topical Voriconazole.<jats:italic>Method<\/jats:italic>. A case report.<jats:italic>Results<\/jats:italic>. A 52-year-old diabetic male presented with a one-week history of foreign body sensation of the left eye, self-medicated with Neomycin, Polymyxin B, and Dexamethasone eye drops, and was diagnosed to have bacterial conjunctivitis, which was treated with Levofloxacin drops. The patient developed a corneal opacity after 2 days and was initially seen with a visual acuity of counting fingers on the left eye, with a 3\u2009mm central corneal ulcer with feathery borders. No hypopyon was noted. The right eye had a visual acuity of 20\/20 and had unremarkable findings. Corneal scraping of the ulcer showed no organisms on Gram and Giemsa stain. Cultures were positive for<jats:italic>Drechslera<\/jats:italic>spp. and patient was started on Natamycin drops every 15 minutes, Atropine drops 3\u00d7 a day, and Levofloxacin was continued every 4 hours. The ulcer increased to 4\u2009mm, the infiltrates became deeper involving the midstroma, and there was appearance of a 2\u2009mm hypopyon. Natamycin was shifted to Voriconazole eye drops every 15 minutes. There was note of a decrease in the size of the ulcer and clearing of the infiltrates with the new treatment regimen. Final visual acuity after 29 days of treatment was 20\/40 with note of a slight corneal haze in the area of the previous ulcer.<jats:italic>Conclusion<\/jats:italic>. Voriconazole may be safe and effective in the treatment of<jats:italic>Drechslera<\/jats:italic>keratitis. There was no perforation and there was immediate decrease in the size of the ulcer. This is the first known case of<jats:italic>Drechslera<\/jats:italic>keratitis treated with Voriconazole eye drops in the Philippines.<\/jats:p>","DOI":"10.1155\/2013\/626704","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T17:03:27Z","timestamp":1379523807000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Fungal Keratitis Caused by<i>Drechslera<\/i>spp. Treated with Voriconazole: A Case Report"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-7583","authenticated-orcid":true,"given":"Margarita I.","family":"Echavez","sequence":"first","affiliation":[{"name":"External Disease and Cornea Service, Department of Ophthalmology and Visual Sciences, Sentro Oftalmologico Jose Rizal, Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Ermita, 1000 Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5804-8424","authenticated-orcid":true,"given":"Archimedes Lee D.","family":"Agahan","sequence":"additional","affiliation":[{"name":"External Disease and Cornea Service, Department of Ophthalmology and Visual Sciences, Sentro Oftalmologico Jose Rizal, Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Ermita, 1000 Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel S.","family":"Carino","sequence":"additional","affiliation":[{"name":"External Disease and Cornea Service, Department of Ophthalmology and Visual Sciences, Sentro Oftalmologico Jose Rizal, Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Ermita, 1000 Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume":"34, supplement 2","journal-title":"Collegium Antropologicum","first-page":"271","key":"1"},{"key":"2","first-page":"91","volume":"20","year":"1976","journal-title":"New Zealand Journal of Agricultural Research"},{"issue":"4","key":"3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/clinids\/7.4.525","volume":"7","year":"1985","journal-title":"Reviews of Infectious Diseases"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2013\/626704.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2013\/626704.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2013\/626704.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T18:08:10Z","timestamp":1498068490000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criopm\/2013\/626704\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":3,"alternative-id":["626704","626704"],"URL":"https:\/\/doi.org\/10.1155\/2013\/626704","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2013]]}}}