{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:01:58Z","timestamp":1791619318627,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T00:00:00Z","timestamp":1359936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013,2,4]]},"abstract":"<jats:p>Mayer-Rokitansky-K\u00fcster-Hauser (MRKH) syndrome is a pathological condition characterized by primary amenorrhea and infertility and by congenital aplasia of the uterus and of the upper vagina. The development of secondary sexual characters is normal as well as that the karyotype (46,XX). Etiologically, this syndrome may be caused by the lack of development of the M\u00fcllerian ducts between the fifth and the sixth weeks of gestation. To explain this condition, it has been suggested that in patients with MRKH syndrome, there is a very strong hyperincretion of M\u00fcllerian-inhibiting factor (MIF), which would provoke the lack of development of the M\u00fcllerian ducts from primitive structures (as what normally occurs in male phenotype). These alterations are commonly associated with renal agenesis or ectopia. Specific mutations of several genes such as WT1, PAX2, HOXA7-HOXA13, PBX1, and WNT4 involved in the earliest stages of embryonic development could play a key role in the etiopathogenesis of this syndrome. Besides, it seems that the other two genes, TCF2 (HNF1B) and LHX1, are involved in the determinism of this pathology. Currently, the most widely nonsurgical used techniques include the \u201cFrank\u2019s dilators method,\u201d while the surgical ones most commonly used are those developed by McIndoe, Williams, Vecchietti, Davydov, and Baldwin.<\/jats:p>","DOI":"10.1155\/2013\/628717","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T21:05:28Z","timestamp":1360011928000},"page":"1-10","source":"Crossref","is-referenced-by-count":64,"title":["Mayer-Rokitansky-Kuster-Hauser Syndrome: Embryology, Genetics and Clinical and Surgical Treatment"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-4928","authenticated-orcid":true,"given":"Alfonsa","family":"Pizzo","sequence":"first","affiliation":[{"name":"Department of Gynaecological and Obstetrical Sciences and Reproductive Medicine, University of Messina, Via C. 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