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As compared with synovitis of RA (pannus), proliferation of PsA synovium is mild and characterized by hypervascularity and increased infiltration of polymorphonuclear leukocytes in the synovial tissues. Angiogenesis plays a crucial role in cutaneous psoriasis, and several angiogenic factors such as vascular endothelial growth factor, interleukin-8, angiopoietin, tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic> and transforming growth factor-<jats:italic>\u03b2<\/jats:italic>, are suggested to play an important role also in the pathophysiology of PsA. Further, IL-17 has various functions such as upregulation of proinflammatory cytokines, attraction of neutrophils, stimulation of keratinocytes, endothelial cell migration, and osteoclast formation via RANKL from activated synovial fibroblasts. Thus, IL-17 may be important in angiogenesis, fibrogenesis, and osteoclastogenesis in PsA. In this paper, roles of angiogenesis in the psoriatic synovium are discussed, which may strengthen the understanding of the pathogenesis of PsA.<\/jats:p>","DOI":"10.1155\/2013\/630620","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T21:16:15Z","timestamp":1369948575000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Angiogenic and Inflammatory Properties of Psoriatic Arthritis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Toshiyuki","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, 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