{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:28:16Z","timestamp":1791872896232,"version":"4.3.4"},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Currently, there is a considerable controversy over the participation of Treg cells during<jats:italic>Trypanosoma cruzi<\/jats:italic>infection, the main point being whether these cells play a negative or a positive role. In this work, we found that the adoptive transfer of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>FOXP3<jats:sup>+<\/jats:sup>T cells from rSSP4- (a recombinant<jats:italic>Trypanosoma cruzi<\/jats:italic>amastigote derived protein, previously shown to have immunomodulatory properties on macrophages) immunized BALB\/c donors into syngenic recipients simultaneously with<jats:italic>T. cruzi<\/jats:italic>challenge reduces cardiac inflammation and prolongs hosts\u2019 survival but increases blood parasitemia and parasite loads in the heart. These CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>FOXP3<jats:sup>+<\/jats:sup>Treg cells from immunized mice have a relatively TGF-<jats:italic>\u03b2<\/jats:italic>-dependent suppressive activity on CD4<jats:sup>+<\/jats:sup>T cells. Therefore, regulatory CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>T cells play a positive role in the development of acute<jats:italic>T. cruzi<\/jats:italic>infection by inducing immunosuppressive activity that controls early cardiac inflammation during acute Chagas disease, prolonging survival, but at the same time promoting parasite growth.<\/jats:p>","DOI":"10.1155\/2013\/632436","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T21:02:15Z","timestamp":1356555735000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Treg Cells Induced by rSSP4 Derived from<i>T. cruzi<\/i>Amastigotes Increase Parasitemia in an Experimental Chagas Disease Model"],"prefix":"10.1155","volume":"2013","author":[{"given":"Y.","family":"Flores-Garc\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, 07360 Mexico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Rosales-Encina","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, 07360 Mexico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. H.","family":"Rosales-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Servicios Generales, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, 07360 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Satoskar","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Pathology, Medical Center, The Ohio State University, Colombus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Talam\u00e1s-Rohana","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, 07360 Mexico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01500-06"},{"issue":"12","key":"2","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1590\/S0100-879X1998001200011","volume":"31","year":"1998","journal-title":"Brazilian Journal of Medical and Biological Research"},{"issue":"3","key":"3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1084\/jem.174.3.539","volume":"174","year":"1991","journal-title":"Journal of Experimental Medicine"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.1.169"},{"issue":"7","key":"5","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.4049\/jimmunol.153.7.3135","volume":"153","year":"1994","journal-title":"Journal of Immunology"},{"issue":"5","key":"6","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.174.5.1209","volume":"174","year":"1991","journal-title":"Journal of Experimental Medicine"},{"issue":"11","key":"7","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","volume":"147","year":"1991","journal-title":"Journal of Immunology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.10.006"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0014-4894(87)90062-2","volume":"64","year":"1987","journal-title":"Experimental Parasitology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2009.05.016"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00729.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/ni743"},{"key":"13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/eji.1830260125","volume":"26","year":"1996","journal-title":"European Journal of Immunology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1211"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.003"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/nri2189"},{"key":"29"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132723"},{"key":"18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.0105-2896.2006.00420.x","volume":"212","year":"2006","journal-title":"Immunological Reviews"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1086\/590439"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.04.009"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2012.01377.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/nri2097"},{"issue":"7","key":"23","first-page":"1093","volume":"7","year":"2011","journal-title":"International Journal of Biological Sciences"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061886"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2008.02167.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000512"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000992"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.04.008"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/632436.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/632436.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/632436.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T05:22:37Z","timestamp":1687929757000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/632436\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":29,"alternative-id":["632436","632436"],"URL":"https:\/\/doi.org\/10.1155\/2013\/632436","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}