{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:18:16Z","timestamp":1762917496046,"version":"3.37.3"},"reference-count":6,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Emergency Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background and Aim<\/jats:italic>. Levetiracetam is a second-generation antiepileptic drug. It is approved as an adjunctive treatment of partial onset seizures with or without secondary generalization. It is considered safe with less than 1% of patients with transient elevations of liver enzymes.<jats:italic>Methods<\/jats:italic>. We report a case of acute liver failure secondary to Levetiracetam in combination with Lacosamide documented with a liver biopsy.<jats:italic>Results<\/jats:italic>. Liver biopsy demonstrated acute liver injury with a predominant submassive necrosis pattern and features of a drug-induced hepatitis.<jats:italic>Conclusions<\/jats:italic>. This is the first published case of acute liver failure due to antiepileptic therapy with Levetiracetam in combination with Lacosamide.<\/jats:p>","DOI":"10.1155\/2013\/634174","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T21:31:45Z","timestamp":1377034305000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Acute Liver Failure Associated with Levetiracetam and Lacosamide Combination Treatment for Unspecified Epileptic Disorder"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ylse","family":"Guti\u00e9rrez-Grobe","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Medica Sur Clinic and Foundation, Puente de Piedra No. 150, Colonia Toriello Guerra, Delegaci\u00f3n Tlalpan, 14050 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3199-7926","authenticated-orcid":true,"given":"Jose Antonio","family":"Bahena-Gonzalez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medica Sur Clinic and Foundation, Puente de Piedra No. 150, Colonia Toriello Guerra, Delegaci\u00f3n Tlalpan, 14050 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Herrera-Gomar","sequence":"additional","affiliation":[{"name":"Coronary Care Unit, Medica Sur Clinic and Foundation, Puente de Piedra No. 150, Colonia Toriello Guerra, Delegaci\u00f3n Tlalpan, 14050 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Mendoza-Diaz","sequence":"additional","affiliation":[{"name":"Coronary Care Unit, Medica Sur Clinic and Foundation, Puente de Piedra No. 150, Colonia Toriello Guerra, Delegaci\u00f3n Tlalpan, 14050 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Garc\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Coronary Care Unit, Medica Sur Clinic and Foundation, Puente de Piedra No. 150, Colonia Toriello Guerra, Delegaci\u00f3n Tlalpan, 14050 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Gonz\u00e1lez-Chon","sequence":"additional","affiliation":[{"name":"Coronary Care Unit, Medica Sur Clinic and Foundation, Puente de Piedra No. 150, Colonia Toriello Guerra, Delegaci\u00f3n Tlalpan, 14050 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2010.0291"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2006.10.002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02966.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9662-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22442"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/hep.510260319","volume":"26","year":"1997","journal-title":"Hepatology"}],"container-title":["Case Reports in Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criem\/2013\/634174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criem\/2013\/634174.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criem\/2013\/634174.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T14:07:51Z","timestamp":1498054071000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criem\/2013\/634174\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":6,"alternative-id":["634174","634174"],"URL":"https:\/\/doi.org\/10.1155\/2013\/634174","relation":{},"ISSN":["2090-648X","2090-6498"],"issn-type":[{"type":"print","value":"2090-648X"},{"type":"electronic","value":"2090-6498"}],"subject":[],"published":{"date-parts":[[2013]]}}}