{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:31:19Z","timestamp":1777498279968,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>BACKGROUND: The worldwide spread of extended\u2010spectrum \u03b2\u2010lactamase (ESBL)\u2010producing Enterobacteriaceae, particularly <jats:italic>Escherichia coli,<\/jats:italic> has significantly limited therapeutic options, especially for urinary tract infections. Although limited in their indications, fosfomycin and tigecycline are potential agents to treat infections due to ESBL\u2010producing organisms. Although not routinely performed, susceptibility testing to both is necessary to ensure there is not an increase in resistance.<\/jats:p><jats:p>METHODS: A total of 160 isolates of ESBL\u2010producing <jats:italic>E coli<\/jats:italic> were isolated from patients at multiple regional hospitals in the Interior Health Region of British Columbia from June 2009 to January 2012. Isolates were obtained from various body fluids and sites including urine (78.2%), wounds, blood, gall bladder drain and respiratory specimens. All isolates were tested using the E\u2010test method (Etest, bioM\u00e9rieux, France) for tigecycline and Kirby Bauer disk diffusion method for fosfomycin using European Committee of Antimicrobial Susceptibility Testing breakpoints for tigecycline and Clinical and Laboratory Standards Institute zone sizes for fosfomycin.<\/jats:p><jats:p>RESULTS: All 160 isolates were found to be susceptible to tigecycline, while five isolates (3.1%) were resistant to fosfomycin (four resistant, one intermediate).<\/jats:p><jats:p>CONCLUSION: Although resistance to these antibiotics has previously been reported, the present study confirmed that isolates of ESBL\u2010producing <jats:italic>E coli<\/jats:italic> from the Interior Health Region of British Columbia remain highly susceptible to both tigecycline and fosfomycin.<\/jats:p>","DOI":"10.1155\/2013\/645018","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:01:35Z","timestamp":1458028895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Determination of Susceptibility to Fosfomycin and Tigecycline of Enterobacteriaceae, Particularly <i>Escherichia coli<\/i> Isolates, Producing Extended\u2010Spectrum \u03b2\u2010Lactamases from Multiple Regional Canadian Hospitals"],"prefix":"10.1155","volume":"24","author":[{"given":"Carlee","family":"Beuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Blondel-Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naowarat","family":"Cheeptham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1]]},"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2013\/645018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2013\/645018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:21:40Z","timestamp":1723072900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2013\/645018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1155\/2013\/645018"],"URL":"https:\/\/doi.org\/10.1155\/2013\/645018","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2013-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}