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However, to analyze clinical data generated using a repeated measures experimental design, the model has been extended to handle multivariate time series data and demonstrated on control and alcoholic subjects taken from data previously analyzed in the temporal domain. Analysis of BOLD data is typically carried out in the time domain where the data has a high temporal correlation. These analyses generally employ parametric models of the hemodynamic response function (HRF) where prewhitening of the data is attempted using autoregressive (AR) models for the noise. However, this data can be analyzed in the Fourier domain. Here, assumptions made on the noise structure are less restrictive, and hypothesis tests can be constructed based on voxel-specific nonparametric estimates of the hemodynamic transfer function (HRF in the Fourier domain). This is especially important for experimental designs involving multiple states (either stimulus or drug induced) that may alter the form of the response function.<\/jats:p>","DOI":"10.1155\/2013\/645043","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T21:02:32Z","timestamp":1371070952000},"page":"1-16","source":"Crossref","is-referenced-by-count":1,"title":["Development of the Complex General Linear Model in the Fourier Domain: Application to fMRI Multiple Input-Output Evoked Responses for Single Subjects"],"prefix":"10.1155","volume":"2013","author":[{"given":"Daniel E.","family":"Rio","sequence":"first","affiliation":[{"name":"Section of Brain Electrophysiology and Imaging, LCTS, NIAAA, National Institutes of Health, 10 Center Drive, MSC 1540, Bethesda, MD, USA"}]},{"given":"Robert R.","family":"Rawlings","sequence":"additional","affiliation":[{"name":"Section of Brain Electrophysiology and Imaging, LCTS, NIAAA, National Institutes of Health, 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