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Early metastasis is typical for the progression of oral cancer. To modulate the cell migration behavior of oral cancer is one of the oral cancer therapies. In this study, the possible modulating effect of CTXIII on oral cancer migration is addressed. In the example of oral squamous carcinoma Ca9\u201022 cells, the cell viability was decreased by CTXIII treatment in a dose\u2010responsive manner. In wound\u2010healing assay, the cell migration of Ca9\u201022 cells was attenuated by CTXIII in a dose\u2010 and time\u2010responsive manner. After CTXIII treatment, the MMP\u20102 and MMP\u20109 protein expressions were downregulated, and the phosphorylation of JNK and p38\u2010MAPK was increased independent of ERK phosphorylation. 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